, Volume 4, Issue 5, pp 401-408

Cross-reactivity of pollen allergens

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Pollen cross-allergenicity has practical implications on the management of inhalant allergy, in both evaluation and therapy, especially with allergen vaccine immunotherapy. The study of cross-reactivity among pollen allergens has expanded beyond investigation of crude extracts to the characterization and cloning of numerous pollen proteins. In this review, the interrelationships between these pollen allergens in the context of botanical systematics are examined, to provide a framework for cross-reactivity understanding. Recommendations for choices in evaluation and therapy are given.