Current Allergy and Asthma Reports

, Volume 3, Issue 1, pp 47–53

Latex-fruit syndrome

  • Carlos Blanco

DOI: 10.1007/s11882-003-0012-y

Cite this article as:
Blanco, C. Curr Allergy Asthma Rep (2003) 3: 47. doi:10.1007/s11882-003-0012-y


Natural rubber latex immunoglobulin E-mediated hypersensitivity is probably one of the most relevant challenges that has been faced in the treatment of allergies during recent years. Additionally, allergen cross-reactivity has arisen as another very important problem, in the difficulty in diagnosing it and in its clinical implications. It is clear that some latex allergens cross-react with plant-derived food allergens, the so-called latex-fruit syndrome, with evident clinical consequences. Although the foods most frequently involved are banana, avocado, kiwi, and chestnut, several others are also implicated. Investigations point to a group of defense-related plant proteins, class I chitinases, which cross-react with a major latex allergen, hevein, as the panallergens responsible for the syndrome. This review focuses on our current understanding of the latex-fruit syndrome.

Copyright information

© Current Science Inc. 2003

Authors and Affiliations

  • Carlos Blanco
    • 1
  1. 1.Servicio de AlergiaHospital Universitario Dr. Negrín, c/Barrenco de la Ballena s/nSpain