Current Allergy and Asthma Reports

, Volume 1, Issue 6, pp 566–571

The diagnosis and treatment of whipple’s disease

  • Thomas Marth

DOI: 10.1007/s11882-001-0066-7

Cite this article as:
Marth, T. Curr Allergy Asthma Rep (2001) 1: 566. doi:10.1007/s11882-001-0066-7


Whipple’s disease is a rare, chronic, and systemic infectious disease caused by the ubiquitously occuring bacterium Tropheryma whippelii. For two reasons, the disease represents a good example for documenting the input of modern molecular-based techniques into pathogenetic, diagnostic, and therapeutic concepts in clinical medicine. First, the unidentified and uncultivable causative organism has been characterized by novel molecular-genetic techniques. Second, in contrast to other chronic inflammatory disorders, clinical manifestations of T. whippelii infection seem to be based on reduced T-cell helper type 1 (TH1) activity. These findings have led to an improved pathophysiologic understanding of the disease and to new aspects in treatment strategies that are discussed in this paper.

Copyright information

© Current Science Inc. 2001

Authors and Affiliations

  • Thomas Marth
    • 1
  1. 1.Deutsche Klinik für DiagnostikWiesbadenGermany