Annals of Dyslexia

, Volume 59, Issue 1, pp 1–11

The role of gene DCDC2 in German dyslexics

  • A. Wilcke
  • J. Weissfuss
  • H. Kirsten
  • G. Wolfram
  • J. Boltze
  • P. Ahnert
Article

DOI: 10.1007/s11881-008-0020-7

Cite this article as:
Wilcke, A., Weissfuss, J., Kirsten, H. et al. Ann. of Dyslexia (2009) 59: 1. doi:10.1007/s11881-008-0020-7

Abstract

Dyslexia is a complex reading and writing disorder with a strong genetic component. In a German case-control cohort, we studied the influence of the suspected dyslexia-associated gene DCDC2. For the first time in a German cohort, we describe association of a 2445 basepair deletion, first identified in an American study. Evidence of association for three DCDC2 single nucleotide polymorphisms (rs807724, rs793862, rs807701), previously identified in German or American cohorts, was replicated. A haplotype of these polymorphisms showed evidence for association as well. Thus, our data further corroborate association of DCDC2 with dyslexia. Analysis of functional subgroups suggests association of investigated DCDC2 variants mainly with nondysphonetic, nonsevere, but probably dyseidetic (surface) dyslexia. Based on the presumed function of DCDC2, our findings point to a role of impaired neuronal migration in the etiology of the disease.

Keywords

DCDC2GeneticsGenetics of dyslexiaGermansSubgroupsSubgroup-specificity

Supplementary material

11881_2008_20_MOESM1_ESM.doc (104 kb)
ESM 1List of Publications on dyslexia and Chromosomes 6 and 15 (DOC 108 KB)

Copyright information

© The International Dyslexia Association 2009

Authors and Affiliations

  • A. Wilcke
    • 1
    • 4
  • J. Weissfuss
    • 2
    • 3
  • H. Kirsten
    • 2
    • 3
  • G. Wolfram
    • 4
  • J. Boltze
    • 1
  • P. Ahnert
    • 2
    • 3
    • 4
    • 5
  1. 1.Fraunhofer-Institute for Cell Therapy and ImmunologyLeipzigGermany
  2. 2.IKIT—Institute for Clinical Immunology and Transfusion MedicineUniversity of LeipzigLeipzigGermany
  3. 3.BBZ—Center for Biotechnology and BiomedicineUniversity of LeipzigLeipzigGermany
  4. 4.TRM—Translational Center for Regenerative MedicineUniversity of LeipzigLeipzigGermany
  5. 5.IMISE—Institute for Medical Informatics, Statistics and EpidemiologyUniversity of LeipzigLeipzigGermany