Air Quality, Atmosphere & Health

, Volume 4, Issue 1, pp 65–78

Nanomaterial interactions with and trafficking across the lung alveolar epithelial barrier: implications for health effects of air-pollution particles

Authors

  • Nazanin R. Yacobi
    • Will Rogers Institute Pulmonary Research CenterUniversity of Southern California
    • Department of Chemical Engineering and Materials ScienceUniversity of Southern California
  • Farnoosh Fazllolahi
    • Will Rogers Institute Pulmonary Research CenterUniversity of Southern California
    • Department of Chemical Engineering and Materials ScienceUniversity of Southern California
  • Yong Ho Kim
    • Will Rogers Institute Pulmonary Research CenterUniversity of Southern California
    • Department of MedicineUniversity of Southern California
  • Arnold Sipos
    • Will Rogers Institute Pulmonary Research CenterUniversity of Southern California
    • Department of MedicineUniversity of Southern California
  • Zea Borok
    • Will Rogers Institute Pulmonary Research CenterUniversity of Southern California
    • Department of MedicineUniversity of Southern California
    • Department of Biochemistry and Molecular BiologyUniversity of Southern California
  • Kwang-Jin Kim
    • Will Rogers Institute Pulmonary Research CenterUniversity of Southern California
    • Department of MedicineUniversity of Southern California
    • Department of Physiology and BiophysicsUniversity of Southern California
    • Department of Pharmacology and Pharmaceutical SciencesUniversity of Southern California
    • Department of Biomedical EngineeringUniversity of Southern California
    • Will Rogers Institute Pulmonary Research CenterUniversity of Southern California
    • Department of MedicineUniversity of Southern California
    • Department of MedicineUniversity of Southern California
    • Department of PathologyUniversity of Southern California
    • Department of Chemical Engineering and Materials ScienceUniversity of Southern California
Article

DOI: 10.1007/s11869-010-0098-z

Cite this article as:
Yacobi, N.R., Fazllolahi, F., Kim, Y.H. et al. Air Qual Atmos Health (2011) 4: 65. doi:10.1007/s11869-010-0098-z

Abstract

Studies on the health effects of air-pollution particles suggest that injury may result from inhalation of airborne ultrafine particles (<100 nm in diameter). Engineered nanomaterials (<100 nm in at least one dimension) may also be harmful if inhaled. Nanomaterials deposited on the respiratory epithelial tract are thought to cross the air-blood barrier, especially via the expansive alveolar region, into the systemic circulation to reach end organs (e.g., myocardium, liver, pancreas, kidney, and spleen). Since ambient ultrafine particles are difficult to track, studies of defined engineered nanomaterials have been used to obtain valuable information on how nanomaterials interact with and traffic across the air-blood barrier of mammalian lungs. Since specific mechanistic information on how nanomaterials interact with the lung is difficult to obtain using in vivo or ex vivo lungs due to their complex anatomy, in vitro alveolar epithelial models have been of considerable value in determining nanomaterial-lung interactions. In this review, we provide information on mechanisms underlying lung alveolar epithelial injury caused by various nanomaterials and on nanomaterial trafficking across alveolar epithelium that may lead to end-organ injury.

Keywords

Epithelial transportNanoparticle traffickingPulmonary toxicityLung injuryUltrafine particlesAir pollution

Copyright information

© Springer Science+Business Media B.V. 2010