Current Treatment Options in Oncology

, Volume 15, Issue 2, pp 171–186

Optimal Therapy for Adult Patients with Acute Myeloid Leukemia in First Complete Remission

Leukemia (JP Dutcher, Section Editor)

DOI: 10.1007/s11864-014-0281-9

Cite this article as:
Wiernik, P.H. Curr. Treat. Options in Oncol. (2014) 15: 171. doi:10.1007/s11864-014-0281-9

Opinion statement

Although it is absolutely clear that postremission therapy is currently necessary to obtain disease-free long-term survivorship for patients with acute myeloid leukemia (AML) in first complete remission (CR), it is not entirely clear what form that treatment should take. High-dose cytarabine is clearly effective and there definitely is a dose-response relationship for cytarabine and remission duration. High-dose cytarabine is effective for younger patients but not elderly patients. It is effective for patients with favorable cytogenetics but it is not clear whether it is effective for patients with intermediate or unfavorable cytogenetics. Furthermore, it is not clear what the most effective and least toxic dose and schedule of high-dose cytarabine is.


Acute myeloid leukemiaHigh-dose cytarabineCytogeneticsLenalidomideClofarabineInterleukin-2Stem cell transplantation

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Cancer Research Foundation of New YorkChappaquaUSA