Current Treatment Options in Oncology

, Volume 12, Issue 2, pp 173–180

Gene Therapy for Mesothelioma

Malignant Mesothelioma

DOI: 10.1007/s11864-011-0153-5

Cite this article as:
Vachani, A., Moon, E. & Albelda, S.M. Curr. Treat. Options in Oncol. (2011) 12: 173. doi:10.1007/s11864-011-0153-5

Opinion statement

Mesothelioma represents an especially good target for gene therapy since few effective therapies exist, the disease remained relatively localized until late in its course, the tumor can be accessed relatively easily through the chest wall, and the thin layer of mesothelial cells offers a large surface area for efficient, rapid, and diffuse gene transfer. Gene therapy trials in mesothelioma have shown safety, and some limited evidence of efficacy. We present a review of clinical trials that have been performed in mesothelioma and describe several new approaches currently being pursued.

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Thoracic Oncology Research LaboratoryUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Thoracic Oncology Research LaboratoryUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Thoracic Oncology Research LaboratoryUniversity of PennsylvaniaPhiladelphiaUSA