Acupuncture in the Oncology Setting: Clinical Trial Update
First Online: 30 November 2010 DOI:
Cite this article as: Capodice, J.L. Curr. Treat. Options in Oncol. (2010) 11: 87. doi:10.1007/s11864-010-0131-3 Opinion statement
Acupuncture, the insertion of sterile needles into acupuncture points of traditional meridians on the body, is a common and effective treatment for a number of supportive care issues in oncology including acute chemotherapy-induced nausea and vomiting. In the Integrative Oncology setting, acupuncture and Traditional Oriental Medicine have become more visible and many oncology clinics, academic health centers and comprehensive cancer centers recommend and administer acupuncture treatment. Continued basic studies on the physiologic mechanisms of acupuncture and recent clinical trials of acupuncture for cancer patients are enhancing our knowledge and informing our guidelines. While debates on methodological problems confronting the study of acupuncture remain, the most recent research demonstrates that acupuncture is safe, tolerable and effective for a range of side effects resulting from conventional cancer treatments.
References and Recommended Reading Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Ahn AC, Park M, Shaw JR, et al.:
Electrical impedance of acupuncture meridians: the relevance of subcutaneous collagenous bands
CrossRef PubMed This paper represents recent results demonstrating the relationship of collagenous bands and lower electrical impedance at acupuncture meridians. This finding may provide important insight into the nature of acupuncture meridians and mechanism of action of acupuncture.
Lee BC, Ogay V, Kim KW, et al.:
Acupuncture muscle channel in the subcutaneous layer of rat skin
J Acupunct Meridian Stud
Pomeranz B, Chiu D:
Naloxone blockade of acupuncture analgesia: endorphin implicated
CrossRef The seminal paper demonstrating that acupuncture releases the neurotransmitter, beta-endorphin.
Murotani T, Ishizuka T, Nakazawa H, et al.:
Possible involvement of histamine, dopamine, and noradrenalin in the periaqueductal gray in electroacupuncture pain relief
Hui KK, Marina O, Liu J, et al.:
Acupuncture, the limbic system, and the anticorrelated networks of the brain
CrossRef PubMed A very well designed and reported study demonstrating CNS mechanisms of acupuncture administration.
Hui KK, Marina O, Claunch JD, et al.:
Acupuncture mobilizes the brain’s default mode and its anti-correlated network in healthy subjects
NIH Consensus Conference. Acupuncture. JAMA 1998, 280:1518–1524
Berman BM, Lao L, Langenberg P, et al.:
Effectiveness of acupuncture as adjunctive therapy in osteoarthritis of the knee: a randomized, controlled trial
Ann Intern Med
PubMed The largest phase III trial of acupuncture for knee osteoarthritis.
National Institutes of Health Consensus Panel. Acupuncture: National Institutes of Health Consensus Development Conference Statement. National Institutes of Health Web site. Accessed at
on June 22, 2007. Viewed October 28, 2010
The updated consensus statement from 10 years previously (reference 7).
Raphael J, Ahmedzai S, Hester J,
Cancer pain: part 1: Pathophysiology; oncological, pharmacological, and psychological treatments: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners
CrossRef PubMed A comprehensive analysis of thoughts on oncologic pain by a consensus of professionals in the United Kingdom.
Raphael J, Hester J, Ahmedzai S, et al.:
Cancer pain: part 2: physical, interventional and complimentary therapies; management in the community; acute, treatment-related and complex cancer pain: a perspective from the British Pain Society endorsed by the UK Association of Palliative Medicine and the Royal College of General Practitioners
Schmidt BL, Hamamoto DT, Simone DA, Wilcox GL:
Mechanism of cancer pain
CrossRef A review of the neurophysiologic mechanisms implied in oncologic pain.
Crew KD, Capodice JL, Greenlee H, et al.:
Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer
J Clin Oncol
CrossRef PubMed A randomized, sham controlled clinical trial that follows up on a previous pilot study and cross-sectional analysis.
Mao JJ, Bruner DW, Stricker C,
et al.: Feasibility trial of electroacupuncture for aromatase inhibitor-related arthralgia in breast cancer survivors. Integr Cancer Ther 2009, 8(2):123–129.
Dean-Clower E, Doherty-Gilman AM, Keshaviah A, et al.:
Acupuncture as palliative therapy for physical symptoms and quality of life for advanced cancer patients
Integr Cancer Ther
Luo F, Wang JY:
Modulation of central nociceptive coding by acupoint stimulation
CrossRef PubMed A quick review that explores many related nociceptive mechanisms of action of acupuncture including CNS and peripheral mechanisms.
Qin W, Tian J, Bai L, et al.:
FMRI connectivity analysis of acupuncture effects on an amygdala-associated brain network
Wang W, Liu L, Zhi X, et al.:
Study on the regulatory effect of electro-acupuncture on hegu point (LI4) in cerebral response with functional magnetic resonance imaging
Chin J Integr Med
Hui KK, Liu J, Marina O,
et al.: The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. Neuroimage 2005, 27(3):479–496
Pfister DG, Cassileth BR, Deng GE, et al.:
Acupuncture for pain and dysfunction after neck dissection: results of a randomized controlled trial
J Clin Oncol
CrossRef PubMed A pilot study that examines pain and the related side effect of xerostomia in head and neck cancer patients following neck dissection.
Deng G, Rusch V, Vickers A, et al.:
Randomized controlled trial of a special acupuncture technique for pain after thoracotomy
J Thorac Cardiovasc Surg
Deng G, Hou BL, Holodny AI, et al.:
Functional magnetic resonance imaging (fMRI) changes and saliva production associated with acupuncture at LI-2 acupuncture point: a randomized controlled study
BMC Complement Altern Med
CrossRef PubMed An important clinical trial that examined both symptom amelioration and central mechanisms of acupuncture for xerostomia.
Wong RK, Sagar SM, Chen BJ,
et al.: Phase II randomized trial of acupuncture-like transcutaneous electrical nerve stimulation to prevent radiation-induced xerostomia in head and neck cancer patients. J Soc Integr Oncol 2010, 8(2):35–42
Simcock R, Fallowfield L, Jenkins V:
Group acupuncture to relieve radiation induced xerostomia: a feasibility study
Vickers AJ, Straus DJ, Fearon B, et al.:
Acupuncture for postchemotherapy fatigue: a phase II study
J Clin Oncol
Choi JY, Jung HJ, Kim JI, et al.:
A randomized pilot study of acupuncture as an adjunct therapy in adult asthmatic patients
Suzuki M, Namura K, Ohno Y, et al.:
The effect of acupuncture in the treatment of chronic obstructive pulmonary disease
J Altern Complement Med
Mao JJ, Styles T, Cheville A,
et al.: Acupuncture for nonpalliative radiation therapy-related fatigue: feasibility study. J Soc Integr Oncol 2009, 7(2):52–58
Balk J, Day R, Rosenzweig M, et al.: Pilot, randomized, modified, double-blind, placebo-controlled trial of acupuncture for cancer-related fatigue. J Soc Integr Oncol 2009, 7(1):4–11
Melchart D, Weidenhammer W, Streng A, et al.:
Prospective investigation of adverse effects of acupuncture in 97 733 patients
Arch Intern Med
CrossRef PubMed A large review of the safety of acupuncture in 97,733 German patients.
Ladas EJ, Rooney D, Taromina K, et al.:
The safety of acupuncture in children and adolescents with cancer therapy-related thrombocytopenia
Support Care Cancer
viewed October 29, 2010. An excellent resource for researchers and clinicians reporting actively recruiting, ongoing and closed clinical trials throughout the United States
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