Irish Journal of Medical Science

, Volume 179, Issue 4, pp 623–627

Prevalence and clinical significance of 15 autoantibodies in patients with new-onset systemic lupus erythematosus

Authors

  • W.-X. Li
    • Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical University
  • H.-F. Pan
    • Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical University
  • L.-H. Li
    • Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical University
  • N. Zhang
    • Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical University
  • J. Li
    • Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical University
  • Y.-G. Fan
    • Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical University
  • J.-B. Feng
    • Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical University
  • X.-W. Tang
    • Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical University
  • H. Chen
    • Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical University
  • X.-P. Li
    • Department of RheumatologyAnhui Provincial Hospital
    • Department of Epidemiology and BiostatisticsSchool of Public Health, Anhui Medical University
Brief Report

DOI: 10.1007/s11845-010-0543-x

Cite this article as:
Li, W., Pan, H., Li, L. et al. Ir J Med Sci (2010) 179: 623. doi:10.1007/s11845-010-0543-x

Abstract

Introduction

It is necessary to assay multiple autoantibodies simultaneously in the same group of new-onset systemic lupus erythematosus (SLE) patient.

Aim

To determine the prevalence and clinical significance of 15 autoantibodies in patients with new-onset SLE.

Methods

Twenty new-onset patients with SLE and 32 healthy individuals were enrolled in the present study. Serum levels of 15 autoantibodies were detected by enzyme linked immunosorbent assay. The clinical parameters of the patients were also recorded.

Results

The positive rate of anti-ssDNA was the highest (85%). The positive rates of anti-dsDNA, anti-ssDNA, AHA, anti-SSA, anti-SSB, anti-Sm, anti-U1RNP, AnuA, and rRNP were significantly higher in SLE patients than in nomal controls. In terms of clinical manifestation, there were significant associations of rRNP with photaesthesia and of AHA with nephritis.

Conclusion

Clusters of autoantibodies were identified and associations of antibodies with symptoms were found in new-onset patients with SLE.

Keywords

AutoantibodiesDiagnosisSystemic lupus erythematosus

Copyright information

© Royal Academy of Medicine in Ireland 2010