Irish Journal of Medical Science

, Volume 181, Issue 2, pp 285–287

Mesenteric venous thrombosis secondary to an unsuspected JAK2 V617F-positive myeloproliferative disorder

  • M. G. Bourke
  • S. T. Martin
  • M. O’Dwyer
  • J. Hanaghan
  • F. Bennani
  • M. K. Barry
Case Report

DOI: 10.1007/s11845-009-0331-7

Cite this article as:
Bourke, M.G., Martin, S.T., O’Dwyer, M. et al. Ir J Med Sci (2012) 181: 285. doi:10.1007/s11845-009-0331-7
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Abstract

Background

Mesenteric venous thrombosis (MVT) is a rare but potentially fatal cause of mesenteric ischaemia. It presents insidiously and often diagnosis is made at emergency surgery. In half of the cases MVT develops without a causative factor, while in cases in which a pro-thrombotic state is found to exist MVT may be the first clinically detected consequence of that state. The myeloproliferative disorders (MPD) are known to contribute to the development of pro-thrombotic states. Recently, the JAK2 V617F mutation has been associated with the MPDs.

Conclusion

We describe a case of MVT occurring secondary to an unsuspected MPD, in which the patient was subsequently found to carry this mutation. We highlight the necessity to screen for this mutation in cases of intra-abdominal thromboses so that appropriate systemic anticoagulation may be instituted, and the patient may be followed so as to detect the development of an overt MPD.

Keywords

JAK2 V617F Mesenteric infarction Mesenteric venous thrombosis Myeloproliferative disorders Janus kinase Tyrosine kinase Erythropoeitin receptor 

Copyright information

© Royal Academy of Medicine in Ireland 2009

Authors and Affiliations

  • M. G. Bourke
    • 1
  • S. T. Martin
    • 1
  • M. O’Dwyer
    • 2
    • 3
  • J. Hanaghan
    • 4
  • F. Bennani
    • 5
  • M. K. Barry
    • 1
  1. 1.Department of SurgeryMayo General HospitalMayoIreland
  2. 2.Department of HaematologyMayo General HospitalMayoIreland
  3. 3.University College Hospital GalwayGalwayIreland
  4. 4.Department of RadiologyMayo General HospitalMayoIreland
  5. 5.Department of PathologyMayo General HospitalMayoIreland