Korean Journal of Chemical Engineering

, Volume 30, Issue 1, pp 73–81

Reactive-extraction of 2,3-butanediol from fermentation broth by propionaldehyde: Equilibrium and kinetic study


DOI: 10.1007/s11814-012-0145-6

Cite this article as:
Li, Y., Zhu, J., Wu, Y. et al. Korean J. Chem. Eng. (2013) 30: 73. doi:10.1007/s11814-012-0145-6


An effective process was developed to separate 2,3-butanediol (2,3-BD) from fermentation broth (FB) by reactive-extraction. Propionaldehyde (PRA) was used as reactant and reaction product 2-ethyl-4,5-dimethyl-1,3-dioxolane (EDD) acted as extractant. HCl was selected as catalyst. Appropriate conditions were obtained by experiment as follows: 10 °C, CHCl=0.2mol·L−1, two-stage cross-current extraction, reactant volume ratio (VPRA: VFB) for first stage and second stage is 0.10 and 0.05, respectively. The yield rate of 2,3-butanediol for the whole process can reach 90% w/w, and 2,3-butanediol in the final product can be more than 99% w/w. The novel process required less solution and especially had advantages in treating dilute fermentation broth. Furthermore, equilibrium and kinetic study were investigated on the reaction of propionaldehyde and 2,3-butanediol to provide basic data for process development. The results reveal that reaction enthalpy and activation energy of the reaction were −21.84±2.38 KJ·mol−1 and 51.97±2.84 KJ·mol−1, respectively. Kinetics was well described by pseudo-homogeneous model.

Key words

2,3-ButanediolReactive-extractionKineticsPropionaldehydeFermentation Broth

Copyright information

© Korean Institute of Chemical Engineers, Seoul, Korea 2012

Authors and Affiliations

  • Yanjun Li
    • 1
  • Jiawen Zhu
    • 1
  • Yanyang Wu
    • 1
  • Jiaxian Liu
    • 1
  1. 1.Chemical Engineering Research CenterEast China University of Science & TechnologyShanghaiChina