Solid forms of pharmaceuticals: Polymorphs, salts and cocrystals
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- Sarma, B., Chen, J., Hsi, H. et al. Korean J. Chem. Eng. (2011) 28: 315. doi:10.1007/s11814-010-0520-0
Control and selection of the properties of active pharmaceutical ingredients is a crucial part of the drug development process. One major part of this process is the selection of an appropriate solid form. This review will discuss three major types of crystalline solids, polymorphs, salts and cocrystals and processes used to develop and find these forms.