Korean Journal of Chemical Engineering

, Volume 28, Issue 2, pp 315–322

Solid forms of pharmaceuticals: Polymorphs, salts and cocrystals

Authors

  • Bipul Sarma
    • Department of Chemical EngineeringMassachusetts Institute of Technology
    • Novartis-MIT Center for Continuous Manufacturing
  • Jie Chen
    • Department of Chemical EngineeringMassachusetts Institute of Technology
  • Huai-Ying Hsi
    • Department of Chemical EngineeringMassachusetts Institute of Technology
    • Novartis-MIT Center for Continuous Manufacturing
    • Department of Chemical EngineeringMassachusetts Institute of Technology
    • Novartis-MIT Center for Continuous Manufacturing
Invited Review Paper

DOI: 10.1007/s11814-010-0520-0

Cite this article as:
Sarma, B., Chen, J., Hsi, H. et al. Korean J. Chem. Eng. (2011) 28: 315. doi:10.1007/s11814-010-0520-0

Abstract

Control and selection of the properties of active pharmaceutical ingredients is a crucial part of the drug development process. One major part of this process is the selection of an appropriate solid form. This review will discuss three major types of crystalline solids, polymorphs, salts and cocrystals and processes used to develop and find these forms.

Key words

Solid Forms Polymorphs Pharmaceutical Salts Cocrystals Design Screening Scale-up

Copyright information

© Korean Institute of Chemical Engineers, Seoul, Korea 2011