Korean Journal of Chemical Engineering

, Volume 28, Issue 2, pp 315–322

Solid forms of pharmaceuticals: Polymorphs, salts and cocrystals

  • Bipul Sarma
  • Jie Chen
  • Huai-Ying Hsi
  • Allan S. Myerson
Invited Review Paper

DOI: 10.1007/s11814-010-0520-0

Cite this article as:
Sarma, B., Chen, J., Hsi, HY. et al. Korean J. Chem. Eng. (2011) 28: 315. doi:10.1007/s11814-010-0520-0

Abstract

Control and selection of the properties of active pharmaceutical ingredients is a crucial part of the drug development process. One major part of this process is the selection of an appropriate solid form. This review will discuss three major types of crystalline solids, polymorphs, salts and cocrystals and processes used to develop and find these forms.

Key words

Solid FormsPolymorphsPharmaceutical SaltsCocrystalsDesignScreeningScale-up

Copyright information

© Korean Institute of Chemical Engineers, Seoul, Korea 2011

Authors and Affiliations

  • Bipul Sarma
    • 1
    • 2
  • Jie Chen
    • 1
  • Huai-Ying Hsi
    • 1
    • 2
  • Allan S. Myerson
    • 1
    • 2
  1. 1.Department of Chemical EngineeringMassachusetts Institute of TechnologyCambridgeUSA
  2. 2.Novartis-MIT Center for Continuous ManufacturingCambridgeUSA