Biased immunoglobulin genes rearrangement in mantle cell lymphoma: Hints to identify the normal B-cell counterpart
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- Zhang, H., Wang, H., Hao, X. et al. Clin. Oncol. Cancer Res. (2011) 8: 65. doi:10.1007/s11805-011-0561-0
Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma, originating from naïve B-cells. The blastoid MCL tumors often show complex cytogenetic aberrations. In this review, we summarized the data available on immunoglobulin heavy-chain (IgH) genes rearrangement for their importance in suggesting the MCL normal counterpart B-cell. Some new data suggesting an antigen selection process were also presented in this review.