Biased immunoglobulin genes rearrangement in mantle cell lymphoma: Hints to identify the normal B-cell counterpart

  • Hui-lai Zhang
  • Hua-qing Wang
  • Xi-shan Hao
  • Daniela Capello
  • Sergio B. Cogliatti
  • Francesco Bertoni
  • Franco Cavalli
Article

DOI: 10.1007/s11805-011-0561-0

Cite this article as:
Zhang, H., Wang, H., Hao, X. et al. Clin. Oncol. Cancer Res. (2011) 8: 65. doi:10.1007/s11805-011-0561-0

Abstract

Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma, originating from naïve B-cells. The blastoid MCL tumors often show complex cytogenetic aberrations. In this review, we summarized the data available on immunoglobulin heavy-chain (IgH) genes rearrangement for their importance in suggesting the MCL normal counterpart B-cell. Some new data suggesting an antigen selection process were also presented in this review.

Key words

mantle cell lymphomaimmunoglobulin genessomatic hypermutation

Copyright information

© Tianjin Medical University Cancer Institute and Hospital and Springer Berlin Heidelberg 2011

Authors and Affiliations

  • Hui-lai Zhang
    • 1
    • 2
  • Hua-qing Wang
    • 2
  • Xi-shan Hao
    • 2
  • Daniela Capello
    • 3
  • Sergio B. Cogliatti
    • 4
  • Francesco Bertoni
    • 1
  • Franco Cavalli
    • 1
  1. 1.Laboratory of Experimental OncologyOncology Institute of Southern Switzerland (IOSI)BellinzonaSwitzerland
  2. 2.Department of Lymphoma, Tianjin Medical University Cancer Hospital and InstituteKey Laboratory of Cancer Prevention and TherapyTianjinChina
  3. 3.Division of Hematology, Department of Clinical and Experimental Medicine & Centro Interdisciplinare di Biotecnologie per la Ricerca Medica Applicata“Amedeo Avogadro” University of Eastern PiedmontNovaraItaly
  4. 4.Department of PathologyState HospitalSt.GallenSwitzerland