Chinese Journal of Clinical Oncology

, Volume 4, Issue 2, pp 77–82

Studies of differentially-expressed genes in human endometrial cancer of various differentiated grades

  • Bin Cai
  • David Hogg
  • Guangzhong Lu
  • Ling Liu
  • Xiaowei Xi
  • Wei Xu
  • Huifang Lu
  • Yongbin Yang
  • Xiaoping Wan
Article

DOI: 10.1007/s11805-007-0077-9

Cite this article as:
Cai, B., Hogg, D., Lu, G. et al. Chin. J. Clin. Oncol. (2007) 4: 77. doi:10.1007/s11805-007-0077-9

Abstract

Objective

To study the gene expression profiles of human endometrial cancers at various differentia0ted grade levels and to identify the genes related to differentiation of the endometrial cancers.

Methods

cDNA microarray technology was used to analyze the differentially-expressed genes among different differentiated grades of 32 cases of endometrial cancer. Hierarchical cluster analysis (HCA) for the gene expression profiles of the cases was employed.

Results

The tissue samples were grouped based on the various differentiated tumor grades with 33 differentiation-related genes identified out (P<0.001). Based on the results from the HCA, the conformity rate was 91% among the 33 differentially-expressed genes and the analysis of pathological classification.

Conclusion

Genes related to the differentiation of endometrial cancer can be identified by using gene chips to analyze the expression profiles of endometrial cancers at various differentiated grades; HCA of the gene expression profiles can be helpful for distinguishing high-risk endometrial cancers before surgery.

Keywors

cDNA microarray endometrial tumor gene expression profile hierarchical cluster analysis 

Copyright information

© Tianjin Medical University Cancer Institute and Hospital 2007

Authors and Affiliations

  • Bin Cai
    • 1
  • David Hogg
    • 2
  • Guangzhong Lu
    • 3
  • Ling Liu
    • 1
    • 2
  • Xiaowei Xi
    • 1
  • Wei Xu
    • 1
  • Huifang Lu
    • 1
  • Yongbin Yang
    • 1
  • Xiaoping Wan
    • 1
  1. 1.Department of Obstetrics and GynecologyShanghai Jiao Tong University Affiliated First People’s HospitalShanghaiChina
  2. 2.Departments of Medicine and Medical BiophysicsUniversity of TorontoTorontoCanada
  3. 3.Department of PathologyShanghai Jiao Tong University Affiliated First People’s HospitalShanghaiChina