, Volume 1, Issue 4, pp 655-672
Date: 11 Apr 2008

A Tutorial on Computational Cluster Analysis with Applications to Pattern Discovery in Microarray Data

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Abstract.

Microarrays offer unprecedented possibilities for the so-called omic, e.g., genomic and proteomic, research. However, they are also quite challenging data to analyze. The aim of this paper is to provide a short tutorial on the most common approaches used for pattern discovery and cluster analysis as they are currently used for microarrays, in the hope to bring the attention of the Algorithmic Community on novel aspects of classification and data analysis that deserve attention and have potential for high reward.

R. Giancarlo is partially supported by Italian MIUR grants PRIN “Metodi Combinatori ed Algoritmici per la Scoperta di Patterns in Biosequenze” and FIRB “Bioinformatica per la Genomica e la Proteomica” and Italy-Israel FIRB Project “Pattern Discovery Algorithms in Discrete Structures, with Applications to Bioinformatics”. D. Scaturro is supported by a MIUR Fellowship in the Italy-Israel FIRB Project “Pattern Discovery Algorithms in Discrete Structures, with Applications to Bioinformatics”.