Physical activity and fitness in women with metastatic breast cancer
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This study aimed to explore differences in physical activity and fitness between women with metastatic breast cancer compared to healthy controls and factors associated with their physical activity levels.
Seventy-one women with metastatic breast cancer, aged (mean (SD)) 57.7 (9.5) and 2.9 (3.1) years after the onset of metastatic disease, and 71 healthy controls aged 55.0 (9.4) years participated. Of those with metastatic disease, 27 % had bone-only metastases, 35 % visceral-only metastases and 38 % bone and visceral metastases. Patient-reported outcomes and physical measures of muscle strength and aerobic fitness assessments were obtained. Participants wore a SenseWear® physical activity monitor over 7 days, and the average steps/day and the time spent in moderate-to-vigorous intensity physical activity were determined.
Women with metastases were significantly (i) less aerobically fit than the control group (25.3 (5.4) vs. 31.9 (6.1) mL • kg−1 • min−1; P < 0.001); (ii) weaker (e.g. lower limb strength for the metastatic and control groups was 53.5 (23.7) vs. 76.0 (27.4) kg, respectively; P < 0.001); (iii) less active, with the metastatic group attaining only 56 % of the mean daily step counts of the healthy women; and (iv) more symptomatic, reporting higher levels of fatigue and dyspnoea (P < 0.001).
Women living in the community with metastatic breast cancer possessed lower aerobic fitness, reduced muscular strength and less daily physical activity compared to healthy counterparts. They also experienced poorer functioning and higher symptom burden.
Implications for Cancer Survivors
Women living with metastatic breast cancer may benefit from a physical activity programme to address their physical impairments.
- Physical activity and fitness in women with metastatic breast cancer
Journal of Cancer Survivorship
Volume 8, Issue 4 , pp 647-656
- Cover Date
- Print ISSN
- Online ISSN
- Springer US
- Additional Links
- Physical activity
- Metastatic breast cancer
- Industry Sectors
- Author Affiliations
- 1. Faculty of Health Sciences, The University of Sydney, Lidcombe, Australia
- 2. The Chris O’Brien Lifehouse, Camperdown, Australia
- 3. Westmead Cancer Care Centre, Westmead Hospital, The University of Sydney, Sydney, Australia
- 4. Faculty of Health Sciences, Flinders University, Daw Park, Australia
- 5. General Practice and Primary Care Academic Centre, University of Melbourne, Parkville, Australia
- 6. Department of General Practice, University of Western Australia, Crawley, Australia
- 7. Cunningham Centre for Palliative Care, The University of Notre Dame Australia, Darlinghurst, Australia
- 8. Clinical Trials Centre, The University of Sydney, Camperdown, Australia
- 9. St Vincent’s Clinical School, University of New South Wales, Darlinghurst, Australia