Journal of Cancer Survivorship

, Volume 6, Issue 1, pp 45–53

Physical activity among adult survivors of childhood lower-extremity sarcoma

  • Meredith A. Wampler
  • Mary Lou Galantino
  • Sujuan Huang
  • Laura S. Gilchrist
  • Victoria G. Marchese
  • G. Stephen Morris
  • David A. Scalzitti
  • Melissa M. Hudson
  • Kevin C. Oeffinger
  • Marilyn Stovall
  • Wendy M. Leisenring
  • Gregory T. Armstrong
  • Leslie L. Robison
  • Kirsten K. Ness
Article

DOI: 10.1007/s11764-011-0187-5

Cite this article as:
Wampler, M.A., Galantino, M.L., Huang, S. et al. J Cancer Surviv (2012) 6: 45. doi:10.1007/s11764-011-0187-5
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Abstract

Introduction

Adult survivors of childhood lower-extremity sarcoma are largely physically inactive, a behavior which potentially compounds their health burden. Altering this behavior requires understanding those factors that contribute to their physical inactivity. Therefore, this investigation sought to identify factors associated with inactivity in this subpopulation of cancer survivors.

Methods

Demographic, personal, treatment, and physical activity information from adult survivors of childhood lower-extremity sarcomas was obtained from the Childhood Cancer Survivor Study (CCSS) cohort. Generalized linear models were used to identify variables that best identified those individuals who were physically inactive.

Results

Only 41% of survivors met Center for Disease Control (CDC) activity guidelines. Survivors were 1.20 (95% confidence intervals (CI) 1.11–1.30) more likely compared to CCSS sibling cohort and 1.12 (95% CI 1.10–1.15) times more likely than the general population to fail to meet CDC guidelines. Significant predictors of physical inactivity included female sex, hemipelvectomy surgery, and platinum and vinca alkaloid chemotherapy.

Conclusions

The primary findings of this study are that survivors of childhood onset lower-extremity sarcoma are (1) highly likely to be physically inactive and (2) less likely than their siblings or the general population to regularly exercise. This study has identified treatment-related risk factors associated with inactivity that will help health and wellness practitioners develop successful exercise interventions to help these survivors achieve recommended levels of physical activity for health.

Implications for cancer survivors

These results suggest that physical activity interventions for adult survivors of childhood lower-extremity sarcomas should be sex specific and responsive to unique physical late effects experienced by these survivors.

Keywords

Childhood cancerPhysical activityExerciseLate effectsSedentary

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Meredith A. Wampler
    • 1
  • Mary Lou Galantino
    • 2
    • 10
  • Sujuan Huang
    • 3
  • Laura S. Gilchrist
    • 4
    • 11
  • Victoria G. Marchese
    • 5
    • 12
  • G. Stephen Morris
    • 6
  • David A. Scalzitti
    • 7
  • Melissa M. Hudson
    • 3
  • Kevin C. Oeffinger
    • 8
  • Marilyn Stovall
    • 6
  • Wendy M. Leisenring
    • 9
  • Gregory T. Armstrong
    • 3
  • Leslie L. Robison
    • 3
  • Kirsten K. Ness
    • 3
  1. 1.Harrison Medical Center, Outpatient RehabilitationBremertonUSA
  2. 2.Adjunct Research Scholar, University of PennsylvaniaPhiladelphiaUSA
  3. 3.St. Jude Children’s Research HospitalMemphisUSA
  4. 4.St. Catherine UniversityMinneapolisUSA
  5. 5.Penn State Hershey College of Medicine at The Pennsylvania State UniversityHersheyUSA
  6. 6.University of Texas M. D. Anderson Cancer CenterHoustonUSA
  7. 7.American Physical Therapy AssociationAlexandriaUSA
  8. 8.Memorial Sloan Kettering Cancer CenterNew YorkUSA
  9. 9.Fred Hutchinson Cancer Research CenterSeattleUSA
  10. 10.Stockton UniversityStocktonUSA
  11. 11.Children’s Hospitals and Clinics of MinnesotaMinneapolisUSA
  12. 12.Lebanon Valley CollegeAnnvilleUSA