Journal of Cancer Survivorship

, Volume 3, Issue 2, pp 89–98

Comorbidities, therapy, and newly diagnosed conditions for women with early stage breast cancer

  • Linda C. Harlan
  • Carrie N. Klabunde
  • Anita H. Ambs
  • Todd Gibson
  • Leslie Bernstein
  • Anne McTiernan
  • Kathleen Meeske
  • Kathy B. Baumgartner
  • Rachel Ballard-Barbash
Article

DOI: 10.1007/s11764-009-0084-3

Cite this article as:
Harlan, L.C., Klabunde, C.N., Ambs, A.H. et al. J Cancer Surviv (2009) 3: 89. doi:10.1007/s11764-009-0084-3
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Abstract

Purpose

To describe comorbidities in breast cancer patients at diagnosis and examine factors associated with self-reported comorbidities 30 months post-diagnosis.

Methods

Nine hundred forty one of 1,171 women had a medical record abstract and a follow-up survey in the Health, Eating, Activity and Lifestyle Study.

Results

We compared our breast cancer cohort to a contemporaneous nationally-representative sample of age, race/ethnicity and education matched women without cancer (n = 865). Breast cancer patients did not have substantially more comorbidities than women without breast cancer. Women with a hospital record of congestive heart failure significantly less often received chemotherapy or radiation following breast conserving surgery. In multivariate analysis, women who received chemotherapy alone (OR = 3.2; 95% CI: 1.5–6.8), chemotherapy plus radiation (OR = 1.9; 95% CI: 1.02–3.7) or radiation plus tamoxifen (OR = 1.9; 95% CI: 1.1–3.2) were significantly more likely to report at least one new comorbid condition following breast cancer diagnosis than women who received no chemotherapy, tamoxifen or radiation. Overall, women who received adjuvant therapy were more likely to have new comorbidities.

Conclusions

Comorbidities were not substantially different in breast cancer patients than the non-cancer matched controls. Future research should focus on efforts to minimize comorbidities related to chemotherapy and other combination therapy.

Keywords

TherapyComorbidityHealthcareDisparitiesHeart diseaseHypertensionDiabetes

Copyright information

© National Cancer Institute 2009

Authors and Affiliations

  • Linda C. Harlan
    • 1
  • Carrie N. Klabunde
    • 1
  • Anita H. Ambs
    • 1
  • Todd Gibson
    • 2
  • Leslie Bernstein
    • 3
  • Anne McTiernan
    • 4
  • Kathleen Meeske
    • 5
  • Kathy B. Baumgartner
    • 6
  • Rachel Ballard-Barbash
    • 1
  1. 1.Applied Research Program, National Cancer InstituteBethesdaUSA
  2. 2.Information Management ServicesSilver SpringUSA
  3. 3.City of Hope National Medical CenterDuarteUSA
  4. 4.Fred Hutchinson Cancer Research CenterSeattleUSA
  5. 5.Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  6. 6.University of LouisvilleLouisvilleUSA