Lung adenocarcinomas with micropapillary components
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Micropapillary adenocarcinoma is becoming increasingly recognized as a prognostically important histological subtype of carcinoma in various organs. This report presents the clinicopathological findings of lung adenocarcinomas with micropapillary components.
A total of 15 patients with micropapillary components were selected between April 2005 and December 2008. The results of their clinical presentation, metastasis to lymph nodes, pleural invasion, pathological stage, and clinical outcomes were evaluated.
In all, 12 patients underwent a lobectomy or bilobectomy with a regional lymph node dissection; 8 showed metastases to the regional lymph nodes at the time of the operation. Altogether, 14 of 15 cases showed lymphovascular invasion; 10 cases were up-staged after the operation because of lymph node metastases or pleural invasion. The duration of follow-up ranged from 1 to 42 months (median 16 months). Seven patients are alive without disease, whereas seven are alive with disease and one patient died of disease.
These results suggest that the micropapillary components are a manifestation of aggressive behavior, as shown by the frequent lymph node metastases and pleural invasion. Surgeons should search more carefully for metastases and conduct a closer follow-up on these patients when this feature is present with lung adenocarcinoma.
- Siriaunkgul S, Tavassoli FA. Invasive micropapillary carcinoma of the breast. Mod Pathol 1993;6:660–662.
- Middleton LP, Tressera F, Sobel ME, Bryant BR, Alburquerque A, Grases P, et al. Infiltrating micropapillary carcinoma of the breast. Mod Pathol 1999;12:499–504.
- Walsh MM, Bleiweiss IJ. Invasive micropapillary carcinoma of the breast: eighty cases of an underrecognized entity. Hum Pathol 2001;32:583–589. CrossRef
- Nassar H. Carcinomas with micropapillary morphology: clinical significance and current concepts. Adv Anat Pathol 2004;11:297–303. CrossRef
- Amin MB, Tamboli P, Merchant SH, Ordóñez NG, Ro J, Ayala AG, et al. Micropapillary component in lung adenocarcinoma: a distinctive histologic feature with possible prognostic significance. Am J Surg Pathol 2002;26:358–364. CrossRef
- Miyoshi T, Satoh Y, Okumura S, Nakagawa K, Shirakusa T, Tsuchiya E, et al. Early-stage lung adenocarcinomas with a micropapillary pattern, a distinct pathologic marker for a significantly poor prognosis. Am J Surg Pathol 2003;27:101–109. CrossRef
- Miyoshi T, Shirakusa T, Ishikawa Y, Iwasaki A, Shiraishi T, Makimoto Y, et al. Possible mechanism of metastasis in lung adenocarcinomas with a micropapillary pattern. Pathol Int 2005;55:419–424. CrossRef
- Tsutsumida H, Nomoto M, Goto M, Kitajima S, Kubota I, Hirotsu Y, et al. A micropapillary pattern is predictive of a poor prognosis in lung adenocarcinoma, and reduced surfactant apoprotein A expression in the micropapillary pattern is an excellent indicator of a poor prognosis. Mod Pathol 2007;20:638–647. CrossRef
- Kawakami T, Nabeshima K, Hamasaki M, Iwasaki A, Shirakusa T, Iwasaki H. Small cluster invasion: a possible link between micropapillary pattern and lymph node metastasis in pT1 lung adenocarcinomas. Virchows Arch 2009;454:61–70. CrossRef
- Mori K, Kitazawa R, Kondo T, Kitazawa S. Lung adenocarcinoma with micropapillary component presenting with metastatic scrotum tumor and cancer-to-cancer metastasis: a case report. Cases J 2008;1:162. CrossRef
- Kamiya K, Hayashi Y, Douguchi J, Hashiguchi A, Yamada T, Izumi Y, et al. Histopathological features and prognostic significance of the micropapillary pattern in lung adenocarcinoma. Mod Pathol 2008;21:992–1001. CrossRef
- Sánchez-Mora N, Presmanes MC, Monroy V, Moreno N, Lara-Martínez JM, Aladro MH, et al. Micropapillary lung adenocarcinoma: a distinctive histologic subtype with prognostic significance: case series. Hum Pathol 2008;39:324–330. CrossRef
- Yamada M, Goto S, Koshika M, Arao T, Fuyama S. Micropapillary component in lung adenocarcinoma generated in emphysema. Kyobu Geka 2007;60:541–545.
- Kawakami T, Nabeshima K, Makimoto Y, Hamasaki M, Iwasaki A, Shirakusa T, et al. Micropapillary pattern and grade of stromal invasion in pT1 adenocarcinoma of the lung: usefulness as prognostic factors. Mod Pathol 2007;20:514–521. CrossRef
- Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC. World Health Organization classification of tumors: pathology and genetics of tumors of the lung, pleura, thymus and heart. Lyon: IARC Press; 2004.
- Tsao MS, Fraser RS. Primary pulmonary adenocarcinoma with enteric differentiation. Cancer 1991;68:1754–1757. CrossRef
- Lung adenocarcinomas with micropapillary components
General Thoracic and Cardiovascular Surgery
Volume 57, Issue 10 , pp 534-539
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- Author Affiliations
- 1. Division of Thoracic Surgery, Matsue Red Cross Hospital, 200 Horomachi, Matsue, Shimane, 690-8506, Japan
- 2. Division of Pathology, Matsue Red Cross Hospital, Shimane, Japan
- 3. Division of Respiratory Medicine, Matsue Red Cross Hospital, Shimane, Japan