, Volume 55, Issue 10, pp 420-424
Date: 12 Oct 2007

Prognosis of smokers following resection of pathological stage I non-small-cell lung carcinoma

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Abstract

Objective

Many patients who undergo surgery for non-small-cell lung cancer (NSCLC) have a smoking habit, which is a risk factor for NSCLC and chronic obstructive pulmonary disease (COPD). In addition, both smoking habits and COPD has been revealed to be a prognostic indicator following surgery for NSCLC. We conducted a multicenter retrospective observational study to address these issues.

Methods

Cigarette smoking and airway obstruction severity were chosen as variables to assess overall and disease-specific survival of 169 patients with pathological stage I primary NSCLC (119 stage IA, 50 stage IB) who underwent resection in 2000.

Results

The overall 5-year survival rates were 91% for patients who had never smoked (n = 66), 88% for ex-smokers (n = 36), and 72% for current smokers (n = 67) (P = 0.04). The never-smoked group had higher ratios for the factors female, pathological IA, adenocarcinoma, and favorable airway obstruction. In a nested analysis of smokers (ex-smokers and current smokers), smoking status and age were independent factors in a multivariate analysis of disease-specific survival, whereas the degree of airway obstruction was not significant.

Conclusion

For smokers who underwent resection of p-stage I NSCLC, current smoking was an unfavorable prognostic factor in an analysis containing the degree of airway obstruction as a variable.

This work was presented at the 16th World Society of Cardio-Thoracic Surgery meeting, Ottawa, Canada, August 2006