General Thoracic and Cardiovascular Surgery

, Volume 55, Issue 10, pp 420–424

Prognosis of smokers following resection of pathological stage I non-small-cell lung carcinoma

  • Noriyoshi Sawabata
  • Shinichiro Miyoshi
  • Akihide Matsumura
  • Mitsunori Ohta
  • Hajime Maeda
  • Hirofumi Sueki
  • Masanobu Hayakawa
  • Meinoshin Okumura
  • Yoshiki Sawa
ORIGINAL ARTICLE

DOI: 10.1007/s11748-007-0159-x

Cite this article as:
Sawabata, N., Miyoshi, S., Matsumura, A. et al. Gen Thorac Cardiovasc Surg (2007) 55: 420. doi:10.1007/s11748-007-0159-x

Abstract

Objective

Many patients who undergo surgery for non-small-cell lung cancer (NSCLC) have a smoking habit, which is a risk factor for NSCLC and chronic obstructive pulmonary disease (COPD). In addition, both smoking habits and COPD has been revealed to be a prognostic indicator following surgery for NSCLC. We conducted a multicenter retrospective observational study to address these issues.

Methods

Cigarette smoking and airway obstruction severity were chosen as variables to assess overall and disease-specific survival of 169 patients with pathological stage I primary NSCLC (119 stage IA, 50 stage IB) who underwent resection in 2000.

Results

The overall 5-year survival rates were 91% for patients who had never smoked (n = 66), 88% for ex-smokers (n = 36), and 72% for current smokers (n = 67) (P = 0.04). The never-smoked group had higher ratios for the factors female, pathological IA, adenocarcinoma, and favorable airway obstruction. In a nested analysis of smokers (ex-smokers and current smokers), smoking status and age were independent factors in a multivariate analysis of disease-specific survival, whereas the degree of airway obstruction was not significant.

Conclusion

For smokers who underwent resection of p-stage I NSCLC, current smoking was an unfavorable prognostic factor in an analysis containing the degree of airway obstruction as a variable.

Key words

Non-small cell lung cancer Smoking COPD Stage I 

Copyright information

© The Japanese Association for Thoracic Surgery 2007

Authors and Affiliations

  • Noriyoshi Sawabata
    • 1
  • Shinichiro Miyoshi
    • 1
  • Akihide Matsumura
    • 2
  • Mitsunori Ohta
    • 3
  • Hajime Maeda
    • 4
  • Hirofumi Sueki
    • 5
  • Masanobu Hayakawa
    • 6
  • Meinoshin Okumura
    • 7
  • Yoshiki Sawa
    • 7
  1. 1.Department of Cardio-Thoracic SurgeryDokkyo Medical University School of MedicineTochigiJapan
  2. 2.National Kinki-Chuou Medical Center for Chest DiseasesOsakaJapan
  3. 3.Osaka Prefecture Medical Center for Respiratory and Allergic DiseaseOsakaJapan
  4. 4.Toneyama National HospitalOsakaJapan
  5. 5.Ohtemae HospitalOsakaJapan
  6. 6.Toyonaka City General HospitalOsakaJapan
  7. 7.Osaka University Graduate School of MedicineOsakaJapan

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