Lipids

, Volume 48, Issue 3, pp 245–250

Sphingolipid Content in the Human Uterus and Pair-Matched Uterine Leiomyomas Remains Constant

Original Article

DOI: 10.1007/s11745-012-3746-2

Cite this article as:
Paweł, K., Chabowski, A. & Górski, J. Lipids (2013) 48: 245. doi:10.1007/s11745-012-3746-2

Abstract

In the present work we sought to investigate the content of sphingolipids (sphingosine, sphinganine, sphingosine-1-phosphate and ceramide) in human fibroids and pair-matched healthy uterus tissue. We demonstrated that, in uterine leiomyomas, the contents of sphingosine, sphinganine, sphingosine-1-phosphate and ceramide remains quite constant. However, a trend towards elevation of ceramide and simultaneous reduction of sphingosine-1 phosphate levels was also noticed. Additionally, in uterine leiomyomas we found relevant activation of both PTEN and MAPK(ERK1/2) signaling pathways with only a minor change in AKT activity and relatively absent HIF-1α/AMPK activation. In conclusion, rather modest changes in sphingolipids are correlated with the activation of PTEN and MAPK(ERK1/2) signaling proteins in human uterine leiomyomas.

Keywords

PTEN MAPK(ERK1/2) AKT HIF-1α Ceramide Sphingolipids Uterine leiomyomas 

Abbreviations

S1P

Sphingosine-1-phosphate

CER

Ceramide

SPH

Sphingosine

SPA

Sphinganine

PTEN

Phosphatase and tensin homolog

MAPK(ERK1/2)

Mitogen activated protein kinase

AKT

V-akt murine thymoma viral oncogene homolog 1

HIF-1α

Hypoxia inducible factor alpha

Copyright information

© AOCS 2012

Authors and Affiliations

  1. 1.Department of Gynecology and Gynecological OncologyMedical University of BialystokBiałystokPoland
  2. 2.Department of PhysiologyMedical University of BialystokBiałystokPoland