Communication

Lipids

, Volume 46, Issue 11, pp 1071-1074

First online:

A Perinatal Palatable High-Fat Diet Increases Food Intake and Promotes Hypercholesterolemia in Adult Rats

  • Tchana Weyll Souza OliveiraAffiliated withDepartment of Food Science, Federal University of Bahia
  • , Carol Góis LeandroAffiliated withDepartment of Physical Education and Sports Science, CAV, Federal University of PernambucoUniversidade Federal de Pernambuco, Núcleo de Educação Física e Ciências do Esporte, Alto do Reservatório Email author 
  • , Tereza Cristina Bomfim de Jesus DeiróAffiliated withDepartment of Food Science, Federal University of Bahia
  • , Gabriela dos Santos PerezAffiliated withDepartment of Food Science, Federal University of Bahia
  • , Darlene da França SilvaAffiliated withDepartment of Food Science, Federal University of Bahia
  • , Janice Izabel DruzianAffiliated withDepartament of Pharmacy, Federal University of Bahia
  • , Ricardo David CoutoAffiliated withDepartament of Pharmacy, Federal University of Bahia
  • , Jairza Maria Barreto-MedeirosAffiliated withDepartment of Food Science, Federal University of Bahia

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Abstract

The main goal of the present study was to evaluate the long-term effects of a perinatal palatable high-fat diet on the food intake and cholesterol profile of adult rats. Male Wistar rats (aged 22 days) were divided into two groups according to their mother’s diet during gestation and lactation (C p, n = 10; pups from control mothers; and HLp n = 10; pups from mothers fed a palatable high-fat diet). At the 76th day, pups were housed individually for 14 days, and daily food consumption was determined during a period of 6 days. Blood from 100-day-old rats was sampled by cardiac puncture. Fasting (12 h) serum glucose, total cholesterol, LDL-C, HDL-C, triglycerides (TG), and VLDL-C levels were determined. The measurement of food intake was higher in the animals submitted to a hyperlipidic diet during the perinatal period. Serum total cholesterol, LDL-C, HDL-C, TG, VLDL-C and glycemia were increased in the HLp group compared to the control group. Our findings show that an early life environment with a high-fat diet can contribute to metabolic disease in later life.

Keywords

Hyperlipidic diet Cholesterolemia Rats Developmental plasticity Critical period of development