Lipids

, Volume 46, Issue 1, pp 81–85

Two New Eicosanoids with a Unique Isovalerianic Acid Ester Moiety from the South China Sea Gorgonian Dichotella gemmacea

  • Chang-Yun Wang
  • Jie Zhao
  • Hai-Yan Liu
  • Chang-Lun Shao
  • Qing-Ai Liu
  • Yang Liu
  • Yu-Cheng Gu
Communication

DOI: 10.1007/s11745-010-3489-x

Cite this article as:
Wang, CY., Zhao, J., Liu, HY. et al. Lipids (2011) 46: 81. doi:10.1007/s11745-010-3489-x

Abstract

Two new eicosanoids with a unique isovalerianic acid ester group at C-12, named dichotellates A (1) and B (2), were isolated from the gorgonian Dichotella gemmacea collected from the South China Sea using bioassay-guided fractionation. Their structures were established on the basis of extensive spectroscopic analysis including one-dimensional (1D) and two-dimensional (2D) NMR as well as high-resolution ESI-MS experiments. These two compounds were evaluated for their lethal activity toward brine shrimp Artemia salina and both showed weak activity.

Keywords

Gorgonian Dichotella gemmacea Eicosanoid Dichotellate A Dichotellate B 

Abbreviations

COSY

Correlation spectroscopy

DEPT

Distortionless enhancement by polarization transfer

ESI

Electrospray ionization

HMBC

Heteronuclear multiple bond correlation

HMQC

Heteronuclear multiple quantum correlation

IR

Infrared

MS

Mass spectrometry

NMR

Nuclear magnetic resonance

Copyright information

© AOCS 2010

Authors and Affiliations

  • Chang-Yun Wang
    • 1
  • Jie Zhao
    • 1
  • Hai-Yan Liu
    • 1
  • Chang-Lun Shao
    • 1
  • Qing-Ai Liu
    • 1
  • Yang Liu
    • 1
  • Yu-Cheng Gu
    • 2
  1. 1.Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and PharmacyOcean University of ChinaQingdaoPeople’s Republic of China
  2. 2.Syngenta, Jealott’s Hill International Research CentreBracknellUK