Lipids

, Volume 45, Issue 7, pp 645–649

Enhanced Bioavailability of Eicosapentaenoic Acid from Fish Oil After Encapsulation Within Plant Spore Exines as Microcapsules

  • Ammar Wakil
  • Grahame Mackenzie
  • Alberto Diego-Taboada
  • J. Gordon Bell
  • Stephen L. Atkin
Communication

DOI: 10.1007/s11745-010-3427-y

Cite this article as:
Wakil, A., Mackenzie, G., Diego-Taboada, A. et al. Lipids (2010) 45: 645. doi:10.1007/s11745-010-3427-y

Abstract

Benefits of eicosapentaenoic acid (EPA) can be enhanced by raising their bioavailability through microencapsulation. Pollen can be emptied to form hollow shells, known as exines, and then used to encapsulate material, such as oils in a dry powder form. Six healthy volunteers ingested 4.6 g of fish oil containing 20% EPA in the form of ethyl ester first alone and then as 1:1 microencapsulated powder of exines and fish oil. Serum bioavailability of EPA was measured by area under curve (AUC0–24). The mean AUC0–24 of EPA from ethyl ester with exine (M = 19.7, SD = 4.3) was significantly higher than ethyl ester without exines (M = 2, SD = 1.4, p < 0.01).The bioavailability of EPA is enhanced by encapsulation by pollen exines.

Keywords

ExinesMicroencapsulationEicosapentaenoic acidBioavailability

Abbreviations

Ar

Argon laser

AUC(0–24)

Area under the curve between time 0–24 h

BHT

Butylated hydroxytoluene

C/M

Chloroform methanol

EPA

Eicosapentaeoic acid

FAME

Fatty acid methyl esters

GLC

Gas liquid chromatography

HeNe

Helium neon

LCPUFA

Long chain poly unsaturated fatty acids

M

Mean

SD

Standard Deviation

SEM

Scanning electron microscopy

SPSS

Statistical Package for the Social Sciences

Copyright information

© AOCS 2010

Authors and Affiliations

  • Ammar Wakil
    • 1
  • Grahame Mackenzie
    • 2
  • Alberto Diego-Taboada
    • 2
  • J. Gordon Bell
    • 3
  • Stephen L. Atkin
    • 1
  1. 1.Hull Royal InfirmaryMichael White Diabetes CentreHullUK
  2. 2.Department of ChemistryUniversity of HullHullUK
  3. 3.Nutrition GroupInstitute of Aquaculture, University of StirlingStirlingUK