Lipids

, Volume 43, Issue 1, pp 55–64

Dietary Structured Lipids and Phytosteryl Esters: Blood Lipids and Cardiovascular Status in Spontaneously Hypertensive Rats

  • Byung Hee Kim
  • Kevin D. Sandock
  • Tom P. Robertson
  • Stephen J. Lewis
  • Casimir C. Akoh
Original Article

DOI: 10.1007/s11745-007-3124-7

Cite this article as:
Kim, B.H., Sandock, K.D., Robertson, T.P. et al. Lipids (2008) 43: 55. doi:10.1007/s11745-007-3124-7

Abstract

This study examined the dietary effects of enzymatically modified sesame oil with caprylic acid (structured lipids, SL) and phytosteryl esters (PE) on blood lipid profiles and cardiovascular parameters of spontaneously hypertensive rats (SHR) fed high-fat and high-cholesterol (HFHC) diets. The dietary groups were: normal diet (control), sesame oil (SO), SL, SO fortified with PE (SOP), and SL fortified with PE (SLP). After 9 weeks of feeding, the body weights, liver weights, and liver weight/body weight ratios in all HFHC-fed groups were higher than controls. Plasma total and LDL cholesterol levels in all HFHC-fed groups were similar to one another but higher than those in controls. Plasma HDL cholesterol levels in rats fed SOP and SLP were higher than those in controls or rats fed SO and SL. Plasma HDL/total cholesterol ratios in rats fed SOP and SLP were similar to those in controls and were higher than those in rats fed SO and SL. There was no difference in plasma lipid profiles between rats fed SO and SL. Arterial blood pressures (BP) in conscious HFHC-fed rats were similar to those in controls whereas heart rates (HR) in all HFHC-fed groups were similar to one another but were higher than that in controls. These findings demonstrate that (1) the dietary effects of SL on plasma lipid profiles and resting BP and HR are similar to those of SO, (2) PE had positive effects on plasma lipid profiles, and (3) 9-week intake of SL and PE did not have pronounced effects on resting BP but induced tachycardia in SHR.

Keywords

Sesame oilStructured lipidsPhytosteryl estersPlasma lipid profilesSpontaneously hypertensive ratsCardiovascular parameters

Abbreviations

BP

Arterial blood pressures

DBP

Diastolic arterial blood pressures

HDL

High density lipoprotein

HFHC

High-fat and high-cholesterol

HR

Heart rates

LCT

Long chain triacylglycerol

LDL

Low density lipoprotein

MAP

Mean arterial blood pressures

MLM-type

Type of triacylglycerols containing medium chain fatty acids esterified at sn-1,3 positions and long chain fatty acids at sn-2 position

PE

Phytosteryl esters

PP

Arterial pulse pressures

SBP

Systolic arterial blood pressures

SHR

Spontaneously hypertensive rats

SL

Structured lipids

SLP

Structured lipids fortified with phytosteryl esters

SO

Sesame oil

SOP

Sesame oil fortified with phytosteryl esters

Copyright information

© AOCS 2007

Authors and Affiliations

  • Byung Hee Kim
    • 1
  • Kevin D. Sandock
    • 2
  • Tom P. Robertson
    • 2
  • Stephen J. Lewis
    • 2
  • Casimir C. Akoh
    • 1
  1. 1.Department of Food Science and TechnologyThe University of GeorgiaAthensUSA
  2. 2.Department of Physiology and PharmacologyThe University of GeorgiaAthensUSA