, 42:1133

Hypolipidemic and Antioxidant Effects of Dietary Curcumin and Capsaicin in Induced Hypercholesterolemic Rats

Original Article

DOI: 10.1007/s11745-007-3120-y

Cite this article as:
Manjunatha, H. & Srinivasan, K. Lipids (2007) 42: 1133. doi:10.1007/s11745-007-3120-y


Health beneficial hypolipidemic and antioxidant influences of dietary spice principles—curcumin, capsaicin alone and in combination included in the diet for 8 weeks were evaluated in induced hypercholesterolemic rats, in order to verify if there is any additive or synergistic effect of these two bioactive compounds. Dietary curcumin (0.2%), capsaicin (0.015%) or their combination significantly countered the hypercholesterolemia brought about by high cholesterol feeding. Hepatic cholesterol was lowered by dietary spice principles only in normal rats. Liver triglyceride levels were lowered in both normal and hypercholesterolemic rats by capsaicin. Curcumin and capsaicin lowered hepatic and blood lipid peroxides in hypercholesterolemic rats, while the effect in blood was additive with their combination. Hepatic ascorbic acid was enhanced by dietary spice principles in normal rats; glutathione was enhanced by their combination only in hypercholesterolemic rats. Activities of serum glutathione reductase, glutathione transferase and catalase and hepatic glutathione reductase in normal rats and serum glutathione peroxidase in hypercholesterolemic rats were enhanced by dietary spice principles. While dietary curcumin and capsaicin normalized the changes in the levels of antioxidant molecules and activities of antioxidant enzymes to a significant extent, this effect was not generally additive when given in combination, and was higher than the individual effects only in a few instances.


Curcumin Capsaicin Lipid profile Antioxidant molecules Antioxidant enzymes 

Copyright information

© AOCS 2007

Authors and Affiliations

  1. 1.Department of Biochemistry and NutritionCentral Food Technological Research InstituteMysoreIndia

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