Lower weight gain and higher expression and blood levels of adiponectin in rats fed medium-chain TAG compared with long-chain TAG
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Previous studies demonstrated that, compared with long-chain TAG (LCT), dietary medium-chain TAG (MCT) could improve glucose tolerance in rats and humans. It has been well established that adiponectin acts to increase insulin sensitivity. The effects of dietary MCT on adiponectin serum concentration and mRNA levels in adipose tissue were studied in rats. Male Spague-Dawley rats were feda diet containing 20% MCT or LCT for 8 wk. After 6 wk of dietary treatment, an oral glucose tolerance test was performed. Rats fed the MCT diet had less body fat accumulation than those fed the LCT diet (P<0.01). The cell diameter of the perirenal adipose tissue, one of the abdominal adipose tissues, was smaller (P<0.01) in the MCT diet group. The serum adiponectin concentration was higher (P<0.01) in the MCT diet group than in the LCT diet group. The adiponectin content in the perirenal adipose tissue was higher (P<0.01) in the MCT diet group. The MCT-fed group had a higher adiponectin mRNA level in their perirenal adipose tissue (P<0.05). The increase of the plasma glucose concentration after glucose administration istration (area under the curve) was smaller (P<0.01) in the MCT diet group than in the LCT diet group. These findings suggest that dietary MCT, compared with LCT, results in a higher serum adiponectin level with trascriptional activation of the adiponectin gene in rats. We speculate that improved lucose tolerance in rats fed an MCT diet may be, at least in part, ascribed to this higher serum adiponectin level.
St-Onge, M.P., and Jones, P.J. (2002) Physiological Effects of Medium-Chain Triglycerides: Potential Agents in the Prevention of Obesity, J. Nutr. 132, 329–332.PubMed
Lavau M.M., and Hashim, S.A. (1978) Effect of Medium Chain Triglyceride on Lipogenesis and Body Fat in the Rat. J. Nutr. 108, 613–620.PubMed
Geliebter, A., Torbay, N., Bracco, E.F., Hashim, S.A., and Van Itallie, T.B. (1983) Overfeeding with Medium-Chain Triglyceride Diet Results in Diminished Deposition of Fat, Am. J. Clin. Nutr. 37, 1–4.PubMed
Tsuji, H., Kasai, M., Takeuchi, H., Nakamura, M., Okazaki, M., and Kondo, K. (2001) Dietary Medium-Chain Triacylglycerols Suppress Accumulation of Body Fat in A double-Blind, Controlled Trial in Healthy Men and Women, J. Nutr. 131, 2853–2859.PubMed
Han, J., Hamilton, J.A., Kirkland, J.L., Corkey, B.E., and Guo, W. (2003) Medium-Chain Oil Reduces Fat Mass and Down-Regulates Expression of Adipogenic Genes in Rats. Obes. Res. 11, 734–744.PubMed
Eckel, R.H., Hanson, A.S., Chen, A.Y., Berman, J.N., Yost, T.J., and Brass, E.P. (1992) Dietary Substitution of Medium-Chain Triglycerides Improves Insulin-Mediated, Glucose Metabolism in NIDDM Subjects, Diabetes 41, 641–647.PubMed
Gavrila, A., Chan, J.L., Yiannakouris, N., Kontogianni, M., Miller, L.C., Orlova, C., and Mantzoros, C.S. (2003) Serum Adiponectin-Levels Are Inversely Associated with Overall and Central Fat Distribution but Are Not Directly Regulated by Acute Fasting or Leptin Administration in Humans: Cross-Sectional and Interventional Studies. J. Clin. Endocrinol. Metab. 88, 4823–4831.PubMedCrossRef
Matsuzuwa, Y., Funahashi, T., Kihara, S., and Shimomura, I. (2004) Adiponectin and Metabolic Syndrome, Arterioscler. Thromb. Vasc. Biol. 24, 29–33.CrossRef
Kadowaki, T., Hara, K., Yamauchi, T., Terauchi, Y., Tobe, K., and Nagai, R. (2003) Molecular Mechanism of Insulin Resistance and Obesity, Exp. Biol. Med. 228, 1111–1117.
Baba, N., Bracco, E.F., and Hashim, S.A. (1982) Enhanced Thermogenesis and Diminished Deposition of Fat in Response to Overfeeding with Diet Containing Medium Chain Triglyceride. Am. J. Clin. Nutr. 35, 678–682.PubMed
American Institute of Nutrition (1993) AIN-93 Purified Diets for Laboratory Rodents: Final Report of the American Institute of Nutrition ad hoc Writing Committee on the Reformulation of the AIN-76A Rodent Diet, J. Nutr. 123, 133–143.
Chen, Q., Chan, L.L., and Li, E.T. (2003) Bitter Melon (Momordica charantia) Reduces Adiposity. Lowers Serum Insulin and Normalizes Glucose Tolerance in Rats Fed a High Fat Diet. J. Nutr. 133, 1088–1093.PubMed
Takeuchi, H., Matsuo, T., Tokuyama, K., Shimomura, Y., and Suzuki, M. (1995) Diet-Induced Thermogenesis Is Lower in Rats Fed a Lard Diet Than in Those Fed a High Oleic Acid Safflower Oil Diet, a Safflower Oil Diet or a Linseed Oil Diet, J. Nutr, 125, 920–925.PubMed
Hirsch, J., and Gallian, E. (1968) Methods for the Determination of Adipose Cell Size in Man and Animals, J. Lipid Res. 9, 110–119.PubMed
Fruebis, J., Tsao, T.S., Javorschi, S., Ebbets-Reed, D., Erickson, M.R., Yen, F.T., Bihain, B.E., and Lodish, H.F. (2001) Proteolytic Cleavage Product of 30-kDa Adipocyte Complement-Related Protein Increases Fatty Acid Oxidation in Muscle and Causes Weight Loss in Mice, Proc. Natl. Acad. Sci. USA 98, 2005–2010.PubMedCrossRef
Stefan, N., Vozarova, B., Funahashi, T., Matsuzawa, Y., Weyer, C., Lindsay, R.S., Youngren, J.F., Havel, P.J., Pratley, R.E., Bogardus, C., et al. (2002) Plasma Adiponectin Concentration Is Associated with Skeletal Muscle Insulin Receptor Tyrosine Phosphorylation, and Low Plasma Concentration Precedes a Decrease in Whole-Body Insulin Sensitivity in Humans. Diabetes 51, 1884–1888.PubMed
Yamauchi, T., Kamon, J., Waki, H., Murakami, K., Motojima, K., Komeda, K., Ide, T., Kubota, N., Terauchi, Y., Tobe, K., et al. (2001) The Mechanisms by Which Both Heterozygous Peroxisome Proliferator-Activated Receptor γ (PPARγ) Deficiency and PPARγ Agonist Improve Insulin Resistance, J. Biol. Chem. 276, 41245–41254.PubMedCrossRef
Maeda, N., Takahashi, M., Funahashi, T., Kihara, S., Nishizawa, H., Kishida, K., Nagaretani, H., Matsuda, M., Komuro, R., Ouchi, N., et al. (2001) PPARγ Ligands Increase Expression and Plasma Concentrations of Adiponectin, an Adipose-Derived Protein, Diabetes 50, 2094–2099.PubMed
Seaton, T.B., Welle, S.L., Warenko, M.K., and Campbell, R.G. (1986) Thermic Effect of Medium-Chain and Long-Chain Triglycerides in Man, Am. J. Clin. Nutr. 44, 630–634.PubMed
Noguchi, O., Takeuchi, H., Kubota, F., Tsuji, H., and Aoyama, T. (2002) Larger Diet-Induced Thermogenesis and Less Body Fat Accumulation in Rats Fed Medium-Chain Triacylgly cerols Than in Those Fed Long-Chain Triacylglycerols, J. Nutr. Sci. Vitaminol. (Tokyo) 48, 524–529.
Rothwell, N.J., Stock, M.J., and Warwick, B.P. (1983) The Effect of High Fat and High Carbohydrate Cafeteria Diets on Diet-Induced Thermogenesis in the Rat, Int. J. Obes. 7, 263–270.PubMed
Landsberg, L., Saville, M.E., and Young, J.B. (1984) Sympathoadrenal System and Regulation of Thermogenesis, Am. J. Physiol. 244, E181-E189.
Lovejoy, J.C. (1999) Dietary Fatty Acids and Insulin Resistance, Curr. Atheroscler. Rep. 1, 215–220.PubMed
Zhang, B., Berger, J., Hu, E., Szalkowski, D., White-Carrington, S., Spiegelman, B.M., and Moller, D.E. (1996) Negative Regulation of Peroxisome Proliferator-Activated Receptor-γ Gene Expression Contributes to the Antiadipogenic Effects of Tumor Necrosis Factor-α, Mol. Endocrinol. 10, 1457–1466.PubMedCrossRef
- Lower weight gain and higher expression and blood levels of adiponectin in rats fed medium-chain TAG compared with long-chain TAG
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