Lipids

, Volume 37, Issue 10, pp 981–989

Comparative effect of fenofibrate on hepatic desaturases in wild-type and peroxisome proliferator-activated receptor α-deficient mice

Authors

  • Hervé Guillou
    • Laboratoire de Biochimie ENSAR-INRA
  • Pascal Martin
    • Laboratoire de Pharmacologie et ToxicologieINRA
  • Sophie Jan
    • Laboratoire de Biochimie ENSAR-INRA
    • Université du Maine
  • Sabine D’Andrea
    • Laboratoire de Biochimie ENSAR-INRA
  • Alain Roulet
    • Laboratoire de Pharmacologie et ToxicologieINRA
  • Daniel Catheline
    • Laboratoire de Biochimie ENSAR-INRA
  • Vincent Rioux
    • Laboratoire de Biochimie ENSAR-INRA
  • Thierry Pineau
    • Laboratoire de Pharmacologie et ToxicologieINRA
    • Laboratoire de Biochimie ENSAR-INRA
Articles

DOI: 10.1007/s11745-006-0990-3

Cite this article as:
Guillou, H., Martin, P., Jan, S. et al. Lipids (2002) 37: 981. doi:10.1007/s11745-006-0990-3

Abstract

In this study is presented the effect of fenofibrate, a prototypical peroxisome proliferator of the fibrate class, on wild-type and peroxisome proliferator-activated receptor α (PPARα)-/-mouse liver FA profile, desaturase mRNA levels, and activities. We established that, following peroxisome proliferator exposure, the hepatic FA profile was greatly modified. These modifications in hepatic FA content required the expression of PPARα, as they are suppressed in transgenic mice deficient in this nuclear receptor. Following peroxisome proliferator exposure, Δ6- and Δ5-desaturase mRNA levels and activities were increased in wild-type but not in PPARα-deficient mouse liver. These results suggest the involvement of PPARα in the control of hepatic Δ6- and Δ5-desaturases in mice. Their roles in minimizing long-chain PUFA depletion in the liver during peroxisome proliferator exposure are discussed.

Abbreviations

AOX

peroxisomal acyl-CoA oxidase

CYP4A10

cytochrome P450 4A10

PP

peroxisome proliferator

PPARα

peroxisome proliferator-activated receptor α

PPRE

peroxisome proliferator responsive element

SCD

stearoyl-CoA desaturase

TBS

Tris-buffered saline

W-T

wild-type

Copyright information

© AOCS Press 2002