Lipids

, Volume 39, Issue 7, pp 617–626

Gestational age and birth weight in relation to n−3 fatty acids among inuit (Canada)

  • Michel Lucas
  • Éric Dewailly
  • Gina Muckle
  • Pierre Ayotte
  • Suzanne Bruneau
  • Suzanne Gingras
  • Marc Rhainds
  • Bruce J. Holub
Articles

DOI: 10.1007/s11745-004-1274-7

Cite this article as:
Lucas, M., Dewailly, É., Muckle, G. et al. Lipids (2004) 39: 617. doi:10.1007/s11745-004-1274-7

Abstract

Seafood consumption during pregnancy carries both benefits (high n−3 FA intake) and risks (exposure to environmental contaminants) for the developing fetus. We determined the impacts of marine n−3 FA and environmental contaminants on gestational age (GA) of Nunavik women and the anthropometric characteristics of their newborns. FA and contaminant (polychlorinated biphenyls and mercury) concentrations were measured in cord plasma of Nuvavik newborns (n=454) and compared with those of a group of newborns (n=29) from southern Québec. Data were collected from hospital records and birth certificates. In Nunavik newborns, arachidonic acid (AA) was two times lower (P<0.0001), whereas DHA concentration, the Σn−3/Σn−6 ratio, and the percentage of n−3 highly unsaturated FA (HUFA) (of the total HUFA) were three times higher (P<0.0001) compared with southern Québec newborns. After controlling for confounders, GA and birth weight were higher by 5.4 d [95% confidence interval (CI): 0.7–10.1] and 77 g (95% CI: −64 to 217) in the third tertile of percentage of n−3 HUFA (of the total HUFA) as compared with the first tertile. There was no evidence that contaminants had negative effects on GA or birth weight. In this seafood-eating population, an increase in the proportion of n−3 HUFA (of the total HUFA), measured in umbilical cord plasma phospholipids, was associated with a significantly longer GA.

Abbreviations

AA

arachidonic acid

ALA

α-linolenic acid

CI

confidence interval

DPA

docosapentaenoic acid

GA

gestational age

HUFA

highly unsaturated FA

LA

linoleic acid

LBW

low birth weight

PCB

polychlorinated biphenyl

PG

prostaglandin

PL

phospholipids

Copyright information

© AOCS Press 2004

Authors and Affiliations

  • Michel Lucas
    • 3
  • Éric Dewailly
    • 3
    • 1
  • Gina Muckle
    • 3
  • Pierre Ayotte
    • 3
  • Suzanne Bruneau
    • 3
  • Suzanne Gingras
    • 3
  • Marc Rhainds
    • 3
  • Bruce J. Holub
    • 2
  1. 1.Department of Social and Preventive MedicineLaval UniversityCanada
  2. 2.Department of Human Biology and Nutritional SciencesUniversity of GuelphGuelphCanada
  3. 3.Public Health Research Unit, Laval University Medical Research CentreCentre Hospitalier Universitaire de Québec (CHUQ)Sainte-FoyCanada

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