Lipids

, Volume 38, Issue 8, pp 805–811

Supplementation with CLA: Isomer incorporation into serum lipids and effect on body fat of women

Authors

  • Anatoli Petridou
    • Department of Physical Education and Sport ScienceTEFAA, University of Thessaloniki
    • Department of Physical Education and Sport ScienceTEFAA, University of Thessaloniki
  • Angelos Sagredos
    • Department of Physical Education and Sport ScienceConsulting
Articles

DOI: 10.1007/s11745-003-1129-2

Cite this article as:
Petridou, A., Mougios, V. & Sagredos, A. Lipids (2003) 38: 805. doi:10.1007/s11745-003-1129-2

Abstract

Animal studies have suggested that CLA, a natural component of meat and dairy products, may confer beneficial effects on health. However, human studies using supplementation with CLA have produced contradictory results. The aim of the present study was to further investigate the effect of CLA supplementation on human body fat, serum leptin, and serum lipids, as well as the incorporation of CLA isomers into serum lipids classes. Sixteen young healthy nonobese sedentary women received 2.1 g of CLA (divided equally between the cis,trans-9,11 and trans,cis-10,12 isomers) daily for 45 d and placebo for 45 d in a randomized double-blind crossover design. Body fat was estimated (by measurement of skinfold thickness at 10 sites), and blood was sampled at the beginning, middle, and end of the entire intervention period; an additional blood sample was obtained 2 wk thereafer. No significant differences in energy, carbohydrate, lipid, or protein intake existed between the CLA and placebo intake periods. No significant differences were found in body fat or serum leptin, TAG, total cholesterol, HDL-cholesterol, and alanine aminotransferase between CLA and placebo. The CLA isomer content of serum TAG, phospholipids, and total lipids increased 2–5 times with CLA supplementation (P<0.05). In contrast, the CLA content of cholesteryl esters did not change significantly. The period of 2 wk after the end of CLA supplementation was sufficient for its washout from serum lipids. These data indicate that supplementation with 2.1 g of CLA daily for 45 d increased its levels in blood but had no effect on body composition or the lipidemic profile of nonobese women.

Abbreviations

ALT

alanine aminotransferase

CE

cholesteryl esters

PL

phospholipids

Copyright information

© AOCS Press 2003