Lipids

, Volume 37, Issue 3, pp 231–236

Cardiac and vascular structure and function are related to lipid peroxidation and metabolism

  • Peter Steer
  • Jonas Millgård
  • Dennis M. Sarabi
  • Samar Basu
  • Bengt Vessby
  • Thomas Kahan
  • Magnus Edner
  • Lars Lind
Articles

DOI: 10.1007/s11745-002-0885-3

Cite this article as:
Steer, P., Millgård, J., Sarabi, D.M. et al. Lipids (2002) 37: 231. doi:10.1007/s11745-002-0885-3
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Abstract

The present study investigated possible relationships between left ventricular mass, intima-media thickness of the carotid artery (IMT), total arterial compliance, and lipid status in a population sample of 58 apparently healthy subjects aged 20 to 69. By stepwise multiple regression analysis, including age, blood pressure, and smoking, left ventricular mass index, measured by M-mode echocardiography, increased by 13.0 g/m2 for each 1 standard deviation (SD=0.11 μM, r=0.60, P<0.01) increase in plasma malondialdehyde and 9.50 g/m2 per SD increase in plasma 8-iso-prostaglandin F in women only (SD=8.88 ng/L, r=0.44, P=0.01). Each 1-SD (SD=0.27 g/L) increase in apolipoprotein B was associated with a 63 μm increase in IMT (r=0.47, P=0.01) and a 0.27 mL/min/m2/mm Hg (r=−0.60, P<0.01) decrease in stroke index/pulse pressure ratio, reflecting total arterial compliance in women. In men, each 1-SD increase in the proportion of stearic acid (18∶0) in serum cholesterol esters (SD=0.12 percent units) reduced the transmitral E/A ratio, measured by Doppler echocardiography, reflecting left ventricular diastolic function, by 0.10 units (r=−0.29, P<0.05). Thus, important cardiovascular characteristics, such as left ventricular mass, left ventricular diastolic function, carotid IMT, and total arterial compliance, were independently predicted by indices of lipid metabolism and peroxidation in apparently healthy subjects.

Abbreviations

AVPD

atrio-ventricular valve plane displacement

CHD

coronary heart disease

EF

ejection fraction

IMT

intima-media thickness

8-iso-PGF

8-iso-prostaglandin F

LVEDD

left ventricular diameter in end-diastole

LVESD

left ventricular diameter in end-systole

LVMI

left ventricular mass index

MDA

malondialdehyde

PL

phospholipid

PP

pulse pressure=systolic blood pressure—diastolic blood pressure

SI

stroke index

Copyright information

© AOCS Press 2002

Authors and Affiliations

  • Peter Steer
    • 1
  • Jonas Millgård
    • 1
  • Dennis M. Sarabi
    • 1
  • Samar Basu
    • 2
  • Bengt Vessby
    • 2
  • Thomas Kahan
    • 3
  • Magnus Edner
    • 3
  • Lars Lind
    • 1
  1. 1.Department of Medical Sciences/Internal MedicineUniversity HospitalUppsalaSweden
  2. 2.Department of Public Health and Caring Sciences/GeriatricsUniversity HospitalUppsalaSweden
  3. 3.Division of Internal MedicineKarolinska Institutet Danderyd HospitalDanderydSweden

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