Changes in conjugated linolenic acid composition within samples obtained from a single source
Purchase on Springer.com
$39.95 / €34.95 / £29.95*
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.
Conjugated linoleic acid (CLA; 9c, 11t-18∶2) and CLA isomers have been reported, in animals, to exhibit a variety of health-related benefits. Silver ion high-performance liquid chromatography (Ag-HPLC) was found to provide better resolution of the isomes than gas chromatography. Most commercially available samples of CLA, prepared by base-catalyzed isomerization of linoleic acid (9c, 12c-18∶2), are conposed of mixtures of four major isomers. While these isomers have been characterized, we found significant changes in CLA isomer ratios within samples obtained from the same producer/commercial supplier over a period of 1.5 yr. In the first sample, the four cis/trans isomers (8t, 10c-18∶2, 9c, 11t-18∶2, 10t, 12c-18∶2 and 11c, 13t-18∶2) were present in a ratio of approximately 1∶2∶2∶1, while in the second sample they were present in almost equal proportions. If indeed certain daily levels of CLA intake are required to produce suggested health benefits in humans, changes in concentrations of specific CLA isomers could significantly impact these effects. Care must be taken to analyze the CLA used in human and animal studies.
- Steinhart, C. (1996) Conjugated Linoleic Acid—the Good News About Animal Fat, J. Chem. Educ. 73, A302-A303. CrossRef
- Ip, C., Briggs, S.P., Haegele, A.D., Thompson, H.J., Storkson, J., and Scimeca, J.A. (1996) The Efficacy of Conjugated Linoleic, Acid in Mammary Cancer Prevention Is Independent of the Level or Type of Fat in the Diet, Carcinogenesis 17, 1045–1050.
- Belury, M.A. (1995) Conjugated Dienoic Linoleate: A Polyunsaturated Fatty Acid with Unique Chemoprotective Properties, Nutr. Rev. 53, 83–89. CrossRef
- Christie, W.W. (1997) The Analysis of Conjugated Fatty Acids, Lipid Technol. (May), 73–75.
- Ha, Y.L., Storkson, J., and Pariza, M.W. (1990) Inhibition of Benzo(A) pyrene-Induced Mouse Forestomach Neoplasia by Conjugated Dienoic Derivatives of Linoleic Acid, Cancer Res. 50, 1097–1101.
- Hubbard, N.E., Lim, D., Summers, L., and Erickson, K.L. (2000) Reduction of Marine Mammary Tumor Metastasis by Conjugated Linoleic Acid, Cancer Lett. 150, 93–100. CrossRef
- MacDonald, H.B. (2000) Conjugated Linoleic Acid and Disease Prevention: A Review of Current Knowledge, J. Am. Coll. Nutr. 19, 111s-118s.
- Rudel, L.L. (1999) Atherosclerosis and Conjugated Linoleic Acid, Br. J. Nutr. 81, 177–179.
- Ma, D.W.L., Wierzbicki, A.A., Field, C.J., and Clandinin, M.T. (1999) Preparation of Conjugated Linoleic Acid from Safflower Oil, J. Am. Oil Chem. Soc. 76, 729–730.
- Chin, S.F., Liu, W., Storkson, J.M., Ha, Y.L., and Pariza, M.W. (1992) Dietary Sources of Conjugated Dienoic Isomers of Linoleic Acid, a Newly Recognized Class of Anticarcinogens, J. Food Comp. Anal. 5, 185–197. CrossRef
- Christie, W.W., Dobson, G., and Gunstone, F. (1997) Isomers in Commercial Samples of Conjugated Linoleic Acid, Lipids 32, 1231. CrossRef
- Park, Y., Storkson, J.M., Albright, K.J., Liu, W., and Pariza, M.W. (1999) Evidence That the trans-10, cis-12 Isomer of Conjugated Linoleic Acid Induces Body Composition Changes in Mice, Lipids 34, 235–241. CrossRef
- Gavino, V.C., Gavino, G., Leblanc, M.J., and Tuchweber, B. (2000) An Isomeric Mixture of Conjugated Linoleic Acids but Not Pure cis-9, trans-11-Octadecadienoic Acid Affects Body Weight Gain and Plasma Lipids in Hamsters, J. Nutr. (Supp.) 130, 27–29.
- Kramer, J.K.G., Sehat, N., Dugan, M.E.R., Mossoba, M.M., Yurawecz, M.P., Roach, J.A.G., Eulitz, K., Aalhus, J.L., Schaefer, A.L., and Ku, Y. (1998) Distributions of Conjugated Linoleic Acid (CLA) Isomers in Tissue Lipid Classes of Pigs Fed a Commercial CLA Mixture Determined by Gas Chromatography and Silver Ion-High-Performance Liquid Chromatography, Lipids 33, 549–558. CrossRef
- Yamasaki, M., Mansho, K., Mishima, H., Kasai, M., Sugano, M., Tachibana, H., and Yamada, K. (1999) Dietary Effect of Conjugated Linoleic Acid on Lipid Levels in White Adipose Tissue of Sprague-Dawley Rats, Biosci. Biotechnol. Biochem. 63, 1104–1106. CrossRef
- Yurawecz, M.P., Sehat, N., Mossoba, M.M., Roach, J.A.G., Kramer, J.K.G., and Ku, Y. (1999) Variations in Isomer Distribution in Commercially Available Conjugated Linoleic Acid, Fett/Lipid 101, 277–282. CrossRef
- Mueller, H. (1996) Diazomethane as a Highly Selective Fatty Acid Methylating Reagent for Use in Gas Chromatographic Analysis, J. Chromatogr. B 679, 208–209.
- Park, Y., Storkson, J.M., Ntambi, J.M., Cook, M.E., Sih, C.J., and Pariza, M.W. (2000) Inhibition of Hepatic Stearoyl-CoA Desaturase Activity by trans-10, cis-12 Conjugated Linoleic Acid and Its Derivatives, Biochim. Biophys. Acta 1486:285–292.
- Changes in conjugated linolenic acid composition within samples obtained from a single source
Volume 36, Issue 3 , pp 315-317
- Cover Date
- Print ISSN
- Online ISSN
- Additional Links
- Industry Sectors