Lipids

, Volume 36, Supplement 1, pp S119–S126

Efficacy of n-3 polyunsaturated fatty acids after myocardial infarction: Results of GISSI-prevenzione trial

Authors

    • Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto MiocardicoAssociazione Nazionale Medici Cardiologi Ospedalieri (ANMCO)
    • Istituto di Ricerche Farmacologiche Mario NegriConsorzio Mario Negri Sud
  • Carlo Schweiger
    • Ospedale di Passirana di Rho
  • Luigi Tavazzi
    • Policlinico San Matteo
  • Franco Valagussa
    • Ospedale di Monza
Article

DOI: 10.1007/s11745-001-0694-8

Cite this article as:
Marchioli, R., Schweiger, C., Tavazzi, L. et al. Lipids (2001) 36: S119. doi:10.1007/s11745-001-0694-8

Abstract

Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardio (GISSI)-Prevenzione was conceived as a population, pragmatic trial on patients with recent myocardial infarctions conducted in the framework of the Italian public health system. In GISSI-Prevenzione, patients were invited to follow Mediterranean dietary habits, and were treated with up-to-date preventive pharmacological interventions. Long-term n-3 PUFA (1 g daily) but not vitamin E (300 mg daily), was beneficial for death and for combined death, nonfatal myocardial infarction, and stroke. All the benefit, however, was attributable to the decrease in risk for overall, cardiovascular, cardiac, coronary, and sudden death.

At variance with the orientation of a scientific scenario largely dominated by the “cholesterol-heart hypothesis”, GISSI-Prevenzione results indicate n-3 PUFA (virtually devoid of any cholesterol-lowering effect) as a relevant pharmacological treatment for secondary prevention after myocardial infarction.

As to the relevance and comparability of GISSI-Prevenzione results, up to 5.7 lives could be saved every 1000 patients with previous myocardial infarction treated with n-3 PUFA (1 g daily) per year. Such a result is comparable to that observed in the Long-Term Intervention with Pravastatin in Ischaemic Disease (LIPID) trial, where 5.2 lives could be saved per 1000 hypercholesterolemic, coronary heart disease patients treated with pravastatin for 1 yr.

The choice of a relatively low-dose regimen (1-g capsule daily) more acceptable for long-term treatment in a population of patients following Mediterranean dietary habits, and the pattern of effects seen in GISSI-Prevenzione (namely, reduction of overall mortality with no decrease in the rate of nonfatal myocardial infarction) all strongly suggest that n-3 PUFA treatment should be considered a recommended new component of secondary prevention. The importance of this combined/additive effect is further suggested by the analyses of the interplay between diet and n-3 PUFA: There is an interesting direct correlation between size of the effect and “correctness” of background diets. It can be anticipated that a conceptual barrier must be overcome: A “dietary drug” should be added to “dietary advice”, which remains fundamental to allow this statement to become true in clinical practice.

Abbreviations

ACE

angiotensin-converting enzyme

CHD

coronary heart disease

CI

confidence interval

DART

Diet and Reinfarction Trial

DHA

docosahexaenoic acid

EPA

eicosapentaenoic acid

GISSI

Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico

PUFA

polyunsaturated fatty acids

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Copyright information

© AOCS Press 2001