Lipids

, Volume 36, Supplement 1, pp S69–S78

n-3 fatty acids: Antiatherosclerotic effects

Article

DOI: 10.1007/s11745-001-0685-9

Cite this article as:
De Caterina, R. & Zampolli, A. Lipids (2001) 36(Suppl 1): S69. doi:10.1007/s11745-001-0685-9

Abstract

The low incidence of cardiovascular disease associated epidemiologically with high consumption of food rich in n-3 fatty acids suggests the possibility that part of the beneficial cardiovascular effects of these natural substances may be due to a reduction of atherosclerosis. This has been recently confirmed in autoptic data and in at least one prospective trial evaluating the progression of coronary atherosclerosis in humans. This paper reviews published literature on n-3 fatty acids and atherosclerosis in animal models and in humans and in vitro experimental data yielding suport to the hypothesis of antiatherosclerotic effects of these substances.

Abbreviations

AA

arachidonic acid

AGE

advanced glycosylation endproducts

ALA

α-linolenic acid

apo

apolipoprotein

DHA

docosahexaenoic acid

ELAM

endothelium-leukocyte adhesion molecules

EPA

eicosapentaenoic acid

HDL

high density lipoprotein

ICAM

intercellular adhesion molecule

IL

interleukin

LDL

low density lipoprotein

LDLR−/−

LDR receptor deficient

LPS

lipopolysaccharide

MCP-1

macrophage chemoattractant protein-1

NF

nuclear factor

PEG

polyethylene glycol

P/S

polyunsaturated/saturated fatty acid ratio

TNF

tumor necrosis factor

VCAM

vascular cell adhesion molecule

VLDL

very low density lipoprotein

WHHL

Watanabe heritable hyperlipidemic rabbits

Copyright information

© AOCS Press 2001

Authors and Affiliations

  1. 1.Department of CardiologyG. d'Annunzio UniversityChietiItaly
  2. 2.CNR Institute of Clinical PhysiologyPisaItaly

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