Prothrombotic burden in a patient with recurrent thrombotic events: might an early assessment of thrombophilia be useful in the presence of a strong family history for vascular events?
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
A 55-year-old man (A. Z.) was admitted to Our Cardiac Step Down Unit of the tertiary center: Careggi Hospital, for an evaluation in the presence of a history of recurrent cardiovascular events.
Classical cardiovascular risk factors:
Hypertension on therapy with a good control, type 2 diabetes mellitus on metformin (3 g/day) with good glycemic control (glycated hemoglobin 5.6 %), high LDL cholesterol levels on statin treatment (rosuvastatin 20 mg/day) reaching a target of LDL 42 mg/dl; low HDL levels (24 mg/dl) on treatment, overweight (BMI 27.6). With regard to family history, almost all his relatives had suffered from a cardiovascular event (Fig. 1) at a young age.Fig. 1
The first thrombotic event occurred at the age of 44 when he had an ischemic stroke without neurological sequelae treated with medical therapy. Aspirin therapy was spontaneously discontinued by the patient after about 4 years.
At the age of 52, he had a STEMI treate ...
- Baglin T, Gray E, Greaves M, Hunt BJ, Keeling D, Machin S, Mackie I, Makris M, Nokes T, Perry D, Tait RC, Walker I, Watson H, British Committee for Standards in Haematology (2010) Clinical guidelines for testing for heritable thrombophilia. Br J Haematol 149:209–220 CrossRef
- Middeldorp S, van HylckamaVlieg A (2008) Does thrombophilia testing help in the clinical management of patients? Br J Haematol 143:321–335 CrossRef
- Vossen CY, Rosendaal FR, EPCOT Study Group (2006) Risk of arterial thrombosis in carriers of familial thrombophilia. J Thromb Haemost 4:916–918 CrossRef
- Inbal A, Freimark D, Modan B, Chetrit A, Matetzky S, Rosenberg N, Dardik R, Baron Z, Seligsohn U (1999) Synergistic effects of prothrombotic polymorphisms and atherogenic factors on the risk of myocardial infarction in young males. Blood 93:2186–2190
- Nordestgaard BG, Chapman MJ, Ray K, Borén J, Andreotti F, Watts GF, Ginsberg H, Amarenco P, Catapano A, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P, Masana L, Reiner Z, Taskinen MR, Tokgözoglu L, Tybjærg-Hansen A, European Atherosclerosis Society Consensus Panel (2010) Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J 31:2844–2853 CrossRef
- Prothrombotic burden in a patient with recurrent thrombotic events: might an early assessment of thrombophilia be useful in the presence of a strong family history for vascular events?
Internal and Emergency Medicine
Volume 8, Issue 6 , pp 543-545
- Cover Date
- Print ISSN
- Online ISSN
- Springer Milan
- Additional Links
- Author Affiliations
- 1. Department of Heart and Vessels, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
- 2. Department of Medical and Surgical Critical Care, University of Florence, Florence, Italy