Internal and Emergency Medicine

, Volume 8, Issue 8, pp 735–740

In-hospital mortality for pulmonary embolism: relationship with chronic kidney disease and end-stage renal disease. The hospital admission and discharge database of the Emilia Romagna region of Italy

Authors

    • Clinica MedicaAzienda Ospedaliera-Universitaria, University of Ferrara
  • Massimo Gallerani
    • First Unit of Internal MedicineAzienda Ospedaliera-Universitaria
  • Marco Pala
    • Clinica MedicaAzienda Ospedaliera-Universitaria, University of Ferrara
  • Alfredo De Giorgi
    • Clinica MedicaAzienda Ospedaliera-Universitaria, University of Ferrara
  • Raffaella Salmi
    • Second Unit of Internal MedicineAzienda Ospedaliera-Universitaria
  • Fabio Manfredini
    • Vascular Disease CenterAzienda Ospedaliera-Universitaria, University of Ferrara
  • Francesco Portaluppi
    • Clinica Medica and Hypertension CenterUniversity Hospital S. Anna and University of Ferrara
  • Francesco Dentali
    • Department of Clinical MedicineUniversity of Insubria
  • Walter Ageno
    • Department of Clinical MedicineUniversity of Insubria
  • Dimitri P. Mikhailidis
    • Department of Clinical Biochemistry (Vascular Disease Prevention Clinics)University College London (UCL) Medical School
  • Roberto Manfredini
    • Clinica Medica and Vascular Diseases CenterAzienda Ospedaliera-Universitaria, University of Ferrara
IM - ORIGINAL

DOI: 10.1007/s11739-012-0892-8

Cite this article as:
Fabbian, F., Gallerani, M., Pala, M. et al. Intern Emerg Med (2013) 8: 735. doi:10.1007/s11739-012-0892-8

Abstract

The impact of chronic kidney disease (CKD) on the outcome of acute pulmonary embolism (PE) is uncertain. We aimed to evaluate the effect of renal dysfunction (defined by ICD-9-CM codification) on in-hospital mortality for PE. We considered all cases of PE (first event) recorded in the database of hospital admissions for the Emilia-Romagna region, Italy, from 1999 to 2009. The inclusion criterion was the presence, as a main discharge diagnosis, of acute PE codes according to ICD-9-CM. Diagnoses of immobilization, dementia, sepsis, skeletal fractures, hypertension, heart failure, myocardial infarction, diabetes mellitus, peripheral vascular disease, cerebrovascular disease, chronic pulmonary disease, pneumonia, malignancy, CKD and end-stage renal disease (ESRD) were also considered to evaluate comorbidity. The outcome was in-hospital mortality for PE, and multivariate logistic regression analyses was performed. We considered 24,690 cases of first episode of PE. In-hospital mortality for PE was not different in patients without renal dysfunction, with CKD, or ESRD (23.6 vs. 24 vs. 18 % p = ns). In-hospital mortality for PE was independently associated with age (OR 1.045, 95 % CI 1.042–1.048, p < 0.001), female sex (OR 1.322, 95 % CI 1.242–1.406, p < 0.001), hypertension (OR 1.096, 95 % CI 1.019–1.178, p = 0.013), diabetes mellitus (OR 1.120, 95 % CI 1.001–1.253, p = 0.049), dementia (OR 1.171, 95 % CI 1.020–1.346, p = 0.025), peripheral vascular disease (OR 1.349, 95 % CI 1.057–1.720, p = 0.016) and malignancy (OR 1.065, 95 % CI 1.016–1.116, p = 0.008). Age and comorbidity are associated with in-hospital mortality for PE, whereas CKD does not appear to be an independent predictor of adverse outcomes in patients hospitalized for PE.

Keywords

Pulmonary embolismMortalityChronic kidney diseaseEnd-stage renal diseaseComorbidityICD-9-CM codification

Copyright information

© SIMI 2012