Renal angiomyolipomatosis and Kaposi’s sarcoma: a possible link disrupted by sirolimus
Rent the article at a discountRent now
* Final gross prices may vary according to local VAT.Get Access
We describe a case of woman aged 72 years, referred to our division for acute kidney injury (AKI). The patient’s history included renal angiomyolipomatosis that caused a previous left nephrectomy, non-Hodgkin Lymphoma (NHL) and cutaneous Kaposi’s sarcoma (KS).
On August 1996, she presented abdominal pain, and underwent abdomen echo tomography that showed multiple renal hyperechogenic images. Enhanced body CT-scan showed multiple renal lesions compatible with angiomyolipomatosis. One year later, she underwent left nephrectomy, and histological analyses confirmed the diagnosis of renal angiomyolipomatosis.
On August 2008, due to the presence of leukopenia and thrombocytopenia, the patient underwent splenectomy and liver biopsy with diagnosis of NHL. A bone marrow biopsy showed a nodular medullary location of NHL. The patient received chemotherapy with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP), for a total of six cycles.
At the end of CHOP cycles, she prese ...
- Taveira-DaSilva, AM, Steagall, WK, Moss, J (2006) Lymphangioleiomyomatosis. Cancer Control 13: pp. 276-285
- Stallone, G, Schena, A, Infante, B, Paolo, S, Loverre, A, Maggio, G, Ranieri, E, Gesualdo, L, Schena, FP, Grandaliano, G (2005) Sirolimus for Kaposi’s sarcoma in renal transplant recipients. N Engl J Med 352: pp. 1317-1323 CrossRef
- Bissler, JJ, McCormack, FX, Young, LR, Elwing, JM, Chuck, G, Leonard, JM, Schmithorst, VJ, Laor, T, Brody, AS, Bean, J, Salisbury, S, Franz, DN (2008) Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N Engl J Med 358: pp. 140-151 CrossRef
- McCormack FX, Inoue Y, Moss J et al; for the National Institutes of Health Rare Lung Diseases Consortium and the MILES Trial Group (2011) Efficacy and safety of sirolimus in lymphangioleiomyomatosis. N Engl J Med 364:1595–1606
- Sodhi, A, Montaner, S, Patel, V, Gómez-Román, JJ, Li, Y, Sausville, EA, Sawai, ET, Gutkind, JS (2004) Akt plays a central role in sarcomagenesis induced by Kaposi’s sarcoma herpesvirus-encoded G protein-coupled receptor. Proc Natl Acad Sci USA 6: pp. 4821-4826 CrossRef
- Renal angiomyolipomatosis and Kaposi’s sarcoma: a possible link disrupted by sirolimus
Internal and Emergency Medicine
Volume 7, Issue 2 Supplement, pp 127-129
- Cover Date
- Print ISSN
- Online ISSN
- Springer Milan
- Additional Links
- Author Affiliations
- 1. Division of Nephrology, Dialysis and Transplantation, Department of Medical and Surgical Sciences, University of Foggia, Viale Luigi Pinto, 1, 71100, Foggia, Italy
- 2. Division of Nephrology, Dialysis and Transplantation, Department of Emergency and Organ Transplantation, University of Bari “Aldo Moro”, Bari, Italy