Internal and Emergency Medicine

, Volume 8, Issue 4, pp 283–289

COPD and the metabolic syndrome: an intriguing association

  • Enrico Clini
  • Ernesto Crisafulli
  • Alessandro Radaeli
  • Mario Malerba
IM - REVIEW

DOI: 10.1007/s11739-011-0700-x

Cite this article as:
Clini, E., Crisafulli, E., Radaeli, A. et al. Intern Emerg Med (2013) 8: 283. doi:10.1007/s11739-011-0700-x

Abstract

Chronic Obstructive Pulmonary Disease (COPD) has been recently recognized as a condition involving more than the lungs. The presence of common factors in COPD and in other chronic extra-pulmonary diseases, as well as the co-existence of these conditions in the same adult individual, supports the hypothesis of a shared pathogenetic pathway. We will here review the interplay between coexisting COPD and the metabolic syndrome (MS), based on the most updated knowledge. We will discuss this clinical condition from the definition, to the pathophysiology and to the clinical implications. Basically, MS is more likely to be present in a COPD patients, and increased levels of circulatory pro-inflammatory proteins from both the lung and adipose tissue coincide in these patients. The relative impact of the coexisting COPD and MS may depend on several factors: the presence of physical inactivity and of systemic inflammation related to a smoking habit, sedentary lifestyle, airway inflammation and obstruction, adipose tissue and inflammatory marker activation. More studies will be required to elucidate the association between COPD and MS and to formulate individualized management approaches for this specific disease phenotype.

Keywords

COPDObesityMetabolismInflammation

Abbreviations

BMI

Body mass index

COPD

Chronic obstructive pulmonary disease

CRP

C-reactive protein

FEV1

Forced expiratory volume in the 1st second

FFA

Free fatty acids

FVC

Forced vital capacity

ICS

Inhaled corticosteroids

IL6

Interleukine 6

IL8

Interleukine 8

MS

Metabolic syndrome

PAI-1

Plasminogen activator inhibitor-1

PaO2

Arterial oxygen pressure

TNFα

Tumour necrosis factor alpha

Copyright information

© SIMI 2011

Authors and Affiliations

  • Enrico Clini
    • 1
    • 2
  • Ernesto Crisafulli
    • 2
  • Alessandro Radaeli
    • 3
  • Mario Malerba
    • 4
  1. 1.Department of Oncology, Haematology and PneumologyUniversity of ModenaModenaItaly
  2. 2.Department of Pulmonary RehabilitationOspedale Villa PinetaPavullo (MO)Italy
  3. 3.Department of EmergencySpedali CiviliBresciaItaly
  4. 4.Department of Internal MedicineUniversity of BresciaBresciaItaly