Internal and Emergency Medicine

, Volume 7, Issue 4, pp 305-311

First online:

The role of statins in stroke

  • Ugo PalianiAffiliated withDivision of Internal Medicine, ASL 1 Umbria Email author 
  • , Stefano RicciAffiliated withDivision of Neurology, Stroke Unit, ASL 1 Umbria

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Although evidence from epidemiological studies examining a relationship between cholesterol level and stroke is less than definitive, there is a compelling evidence from the clinical therapy trials primarily designed to examine the coronary benefits of statins that statin therapy also causes a reduction in the risk of stroke. Even though a stroke does not have the same exact pathophysiology as a heart attack, specific trials in stroke patients confirm advantages and risks of statin therapy in this kind of population. In primary prevention, statins are effective both when low-density lipoprotein (LDL) is raised and when hs-CRP is elevated. In secondary prevention, an absolute reduction of recurrent stroke can be obtained with statins, with a number needed to treat at 5 years of 45.


Statins Ischaemic stroke Cholesterol and stroke