Internal and Emergency Medicine

, Volume 7, Issue 4, pp 305–311

The role of statins in stroke


DOI: 10.1007/s11739-011-0603-x

Cite this article as:
Paliani, U. & Ricci, S. Intern Emerg Med (2012) 7: 305. doi:10.1007/s11739-011-0603-x


Although evidence from epidemiological studies examining a relationship between cholesterol level and stroke is less than definitive, there is a compelling evidence from the clinical therapy trials primarily designed to examine the coronary benefits of statins that statin therapy also causes a reduction in the risk of stroke. Even though a stroke does not have the same exact pathophysiology as a heart attack, specific trials in stroke patients confirm advantages and risks of statin therapy in this kind of population. In primary prevention, statins are effective both when low-density lipoprotein (LDL) is raised and when hs-CRP is elevated. In secondary prevention, an absolute reduction of recurrent stroke can be obtained with statins, with a number needed to treat at 5 years of 45.


StatinsIschaemic strokeCholesterol and stroke

Supplementary material

11739_2011_603_MOESM1_ESM.pdf (26 kb)
Supplementary material 1 (PDF 26 kb)

Copyright information

© SIMI 2011

Authors and Affiliations

  1. 1.Division of Internal MedicineASL 1 UmbriaCittà di Castello (Perugia)Italy
  2. 2.Division of Neurology, Stroke UnitASL 1 UmbriaCittà di Castello (Perugia)Italy