Internal and Emergency Medicine

, Volume 8, Issue 2, pp 101–113

Recent advances in understanding Crohn’s disease

  • Antonio Di Sabatino
  • Laura Rovedatti
  • Francesca Vidali
  • Thomas Thornton MacDonald
  • Gino Roberto Corazza
IM - REVIEW

DOI: 10.1007/s11739-011-0599-2

Cite this article as:
Di Sabatino, A., Rovedatti, L., Vidali, F. et al. Intern Emerg Med (2013) 8: 101. doi:10.1007/s11739-011-0599-2
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Abstract

Crohn’s disease is a chronic inflammatory bowel disorder resulting from an inappropriate innate and acquired immune response to commensal microorganisms in genetically susceptible individuals. This disease has a fluctuating course, with alternating periods of remission and relapses, and it is characterized by a remarkable clinical heterogeneity; it may be complicated by perianal fistulas, abscesses, and intestinal strictures leading to obstructions, besides several systemic manifestations. However, a complete resolution of the disease is currently not possible, yet Crohn’s disease can be managed with established and novel therapies, which achieve long-term remission and acceptable quality of life. This review is focused on novel advances in basic and clinical aspects of Crohn’s disease, although it also deals with new trends in diagnosis and treatment.

Keywords

Chronic inflammation Fistula Inflammatory bowel disease Stricture Therapy 

Abbreviations

CARD15

Caspase activation recruitment domain family-15

CDAI

Crohn’s disease activity index

ECM

Extracellular matrix

18F-FDG-PET

18F-fluorodeoxyglucose positron emission tomography

IFN

Interferon

IL

Interleukin

NOD2

Nucleotide-binding-oligomerization domain-2

Th

T helper cell type

TNF

Tumor necrosis factor

Copyright information

© SIMI 2011

Authors and Affiliations

  • Antonio Di Sabatino
    • 1
    • 3
  • Laura Rovedatti
    • 1
  • Francesca Vidali
    • 1
  • Thomas Thornton MacDonald
    • 2
  • Gino Roberto Corazza
    • 1
  1. 1.First Department of Medicine, Centro per lo Studio e la Cura delle Malattie Infiammatorie Croniche Intestinali, Fondazione IRCCS Policlinico S. MatteoUniversity of PaviaPaviaItaly
  2. 2.Centre for Immunology and Infectious Disease, Blizard Institute of Cell and Molecular ScienceBarts and the London School of Medicine and DentistryLondonUK
  3. 3.Clinica Medica IFondazione IRCCS Policlinico San MatteoPaviaItaly

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