Internal and Emergency Medicine

, Volume 8, Issue 1, pp 33–40

Serum 25-hydroxyvitamin D levels are inversely associated with systemic inflammation in severe obese subjects

Authors

  • Alfonso Bellia
    • Department of Internal MedicineUniversity of Rome “Tor Vergata”
  • Caterina Garcovich
    • Department of Internal MedicineUniversity of Rome “Tor Vergata”
  • Monica D’Adamo
    • Department of Internal MedicineUniversity of Rome “Tor Vergata”
  • Mauro Lombardo
    • Department of Internal MedicineUniversity of Rome “Tor Vergata”
  • Manfredi Tesauro
    • Department of Internal MedicineUniversity of Rome “Tor Vergata”
  • Giulia Donadel
    • Department of Internal MedicineUniversity of Rome “Tor Vergata”
  • Paolo Gentileschi
    • Department of SurgeryUniversity of Rome “Tor Vergata”
  • Davide Lauro
    • Department of Internal MedicineUniversity of Rome “Tor Vergata”
  • Massimo Federici
    • Department of Internal MedicineUniversity of Rome “Tor Vergata”
  • Renato Lauro
    • Department of Internal MedicineUniversity of Rome “Tor Vergata”
    • Department of Internal MedicineUniversity of Rome “Tor Vergata”
IM - ORIGINAL

DOI: 10.1007/s11739-011-0559-x

Cite this article as:
Bellia, A., Garcovich, C., D’Adamo, M. et al. Intern Emerg Med (2013) 8: 33. doi:10.1007/s11739-011-0559-x

Abstract

Obesity is frequently characterized by a reduced vitamin D bioavailability, as well as insulin-resistance and a chronic inflammatory response. We tested the hypothesis of an independent relationship between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and several circulating inflammatory markers in a cohort of severely obese individuals. Cross-sectional study was carried out among obese patients undergoing a clinical evaluation before bariatric surgery in our University Hospital. Serum 25(OH)D, fasting and post load glucose and insulin, high-sensitive C-reactive protein (hs CRP), fibrinogen, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), leptin, adiponectin and lipid profile were collected. Insulin-resistance was assessed by insulin sensitivity index (ISI). Total body fat (FAT kg), total percent body fat (FAT%) and truncal fat mass (TrFAT) were assessed with dual-energy X-ray absorptiometry. A total of 147 obese subjects (89 women, 37.8 ± 7.1 years) with mean body mass index (BMI) of 43.6 ± 4.3 kg/m2 were enrolled. Patients in the lowest tertile of 25(OH)D were significantly more obese with a higher amount of TrFAT, more insulin-resistant, and had higher levels of fasting and post-challenge glucose (p < 0.05 for all). In a multivariate regression analysis, serum 25(OH)D was inversely related to significant levels of hs CRP, IL-6 and TNF-α after accounting for age, gender, season of recruitment, BMI, FAT kg and TrFAT (p < 0.01 for all). In extremely obese subjects, 25(OH)D serum concentrations are inversely associated with several biomarkers of systemic inflammation, regardless of the total quantity of fat mass.

Keywords

Vitamin DInflammationInsulin-resistanceObesity

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© SIMI 2011