Internal and Emergency Medicine

, Volume 6, Issue 1, pp 47–54

Factors associated with mortality in patients with exacerbation of chronic obstructive pulmonary disease hospitalized in General Medicine departments

  • Bernardino Roca
  • Pedro Almagro
  • Francisco López
  • Francisco J. Cabrera
  • Lorena Montero
  • David Morchón
  • Jesús Díez
  • Fernando de la Iglesia
  • Mario Fernández
  • Jesús Castiella
  • Elena Zubillaga
  • Jesús Recio
  • Joan B. Soriano
  • For the ECCO Working Group on COPD, Spanish Society of Internal Medicine
IM - Original

DOI: 10.1007/s11739-010-0465-7

Cite this article as:
Roca, B., Almagro, P., López, F. et al. Intern Emerg Med (2011) 6: 47. doi:10.1007/s11739-010-0465-7

Abstract

We aim to improve knowledge on risk factors that relate to mortality in subjects with exacerbation of chronic obstructive pulmonary disease (COPD) who are hospitalized in General Medicine departments. In a cross-sectional multicenter study, by means of a logistic regression analysis, we assessed the possible association of death during hospitalization with the following groups of variables of participating patients: sociodemographic features, treatment received prior to admission and during hospitalization, COPD-related clinical features recorded prior to admission, comorbidity diagnosed prior to admission, clinical data recorded during hospitalization, laboratory results recorded during hospitalization, and electrocardiographic findings recorded during hospitalization. A total of 398 patients was included; 353 (88.7%) were male, and the median age of the patients was 75 years. Of these patients, 21 (5.3%) died during hospitalization. Only 270 (67.8%) received inhaled β2 agonists during hospitalization, while 162 (40.7%) received angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers. The median of predicted FEV1 prior to admission was 42%. A total of 350 patients (87.9%) had been diagnosed with two or more comorbid conditions prior to admission. An association was found between increased risk of death during hospitalization and the previous diagnoses of pneumonia, coronary heart disease, and stroke. In conclusion, comorbidity is an important contributor to mortality among patients hospitalized in General Medicine departments because of COPD exacerbation.

Keywords

MortalityExacerbationChronic obstructive pulmonary diseaseGeneral medicine departments

Copyright information

© SIMI 2010

Authors and Affiliations

  • Bernardino Roca
    • 1
  • Pedro Almagro
    • 2
  • Francisco López
    • 3
  • Francisco J. Cabrera
    • 4
  • Lorena Montero
    • 5
  • David Morchón
    • 6
  • Jesús Díez
    • 7
  • Fernando de la Iglesia
    • 8
  • Mario Fernández
    • 9
  • Jesús Castiella
    • 10
  • Elena Zubillaga
    • 11
  • Jesús Recio
    • 12
  • Joan B. Soriano
    • 13
  • For the ECCO Working Group on COPD, Spanish Society of Internal Medicine
  1. 1.Hospital General of CastellonUniversity of ValenciaCastellonSpain
  2. 2.Hospital Mútua de TerrassaBarcelonaSpain
  3. 3.Hospital Vega BajaOrihuelaSpain
  4. 4.Hospital GeneralUniversitario Gregorio MarañónMadridSpain
  5. 5.Hospital Comarcal AxarquíaVélez MálagaSpain
  6. 6.Hospital Universitario del Rio HortegaValladolidSpain
  7. 7.Hospital Royo VillanovaZaragozaSpain
  8. 8.Hospital Juan CanalejoLa CoruñaSpain
  9. 9.Hospital GeneralUniversitario 12 de OctubreMadridSpain
  10. 10.Fundación Hospital CalahorraLa RiojaSpain
  11. 11.Hospital DonostiaSan SebastiánSpain
  12. 12.Hospital GeneralUniversitari Vall d’HebronBarcelonaSpain
  13. 13.Fundación Caubet-CimeraCentro Internacional de Medicina Respiratoria AvanzadaBalearesSpain