, Volume 5, Issue 5, pp 371-373
Date: 09 Sep 2010

From Vaquez to Dameshek through JAK…2 much for polycythemia vera to be feared?

This is an excerpt from the content

Clinical practice in modern medicine is a gift that comes from afar. It comes sometimes from a lucky discovery, or sometimes from brave attempt chasing what at that time seemed crazy theories. Anyway, the gift we currently enjoy is the result of careful observation at first, and then like a sculptor with his chisel that free from marble an hidden figure, doctors and researchers carve during the years the features of many diseases.

In this number of the Internal and Emergency Medicine Journal, Landolfi and his co-workers [1] reviewed the principal characteristics of polycythemia vera (PV), starting from the history of the first published description by Luis Henry Vaquez in 1892 [2].

Since this first description something other than plethora and cyanosis were soon identified: the high risk of major thrombotic events potentially leading to death, both in arterial district (acute myocardial infarction, stroke or transient ischemic attack, TIA), and in venous district (deep vein thrombosis, p ...