, Volume 4, Issue 6, pp 521-522
Date: 24 Jun 2009

Clinical trials in heart failure: may we trust?

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Costantino et al. [1] in Internal and Emergency Medicine move from the observation that there is often inconsistency between the results of clinical trials reporting reduction of mortality in heart failure patients by a number of different medications, and those of epidemiological studies, which fail to demonstrate significant improvement in the overall heart failure prognosis. The authors hypothesized that a possible reason for this inconsistency could be represented by the differences between the clinical trial selected populations and the general population and, therefore, they designed a study aimed to compare characteristics of patients referred to their heart failure outpatient clinic with those of patients enrolled in large clinical intervention studies on heart failure pharmacological treatment. They selected 16 studies, involving 45,276 patients, and enrolled a total of 299 consecutive patients from the outpatient clinic of the 2nd Division of Internal Medicine of the L. Sacco ...