, Volume 4, Issue 4, pp 357-358
Date: 14 Jun 2009

Systemic capillary leak syndrome or Clarkson’s disease: a case report

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Systemic capillary leak syndrome (SCLS) is a rare but devastating clinical condition first described by Clarkson et al. [1] in 1960. The last review of this syndrome in 2006 analyzed 75 cases, but only 50 had complete clinical data [2]. Clinically, the syndrome is characterized by hypotension, hypoalbuminemia and hemoconcentration, and is caused by the shift of fluid and protein from the intravascular space to the interstitial space as a result of capillary hyperpermeability. The purpose of this report is to enhance awareness of this syndrome that may be frequently underdiagnosed because of its rarity and wide range of presentation.

In November 2004, the patient, a 46-year-old man in prior good health, was admitted acutely to the hospital for severe hypotension (systemic arterial pressure 70/50 mmHg, heart rate 110 beats per min) generalized edema, cyanosis and altered consciousness. The prior day, he had experienced fever, abdominal pain, dizziness and forearm swelling. Selected labora ...