Internal and Emergency Medicine

, Volume 4, Issue 3, pp 201–211

Contemporary issues on clopidogrel therapy

IM - Review

DOI: 10.1007/s11739-008-0220-5

Cite this article as:
Patti, G. & Di Sciascio, G. Intern Emerg Med (2009) 4: 201. doi:10.1007/s11739-008-0220-5


In this paper, data from available studies regarding some contemporary issues on clopidogrel therapy are analyzed. In particular, the following clinical questions have been considered and addressed: (a) Is early clopidogrel treatment needed in patients with acute coronary syndromes treated medically or undergoing percutaneous coronary intervention (PCI)? (b) What is the optimal clopidogrel loading dose in patients undergoing PCI? (c) Is pre-treatment with clopidogrel before PCI needed, or can clopidogrel loading be given in the catheter laboratory before intervention, but after coronary anatomy is known? (d) What is the optimal clopidogrel strategy in patients on chronic clopidogrel therapy undergoing PCI? (e) Does the degree of clopidogrel response influence clinical outcome in patients undergoing PCI?


ClopidogrelPercutaneous coronary interventionAcute coronary syndromesOutcome

Copyright information

© SIMI 2008

Authors and Affiliations

  1. 1.Department of Cardiovascular SciencesCampus Bio-Medico University of RomeRomeItaly