Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease?
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Until relatively recently, the role of adipose tissue in the development of obesity and its consequences was considered to be a passive one. Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. It is now clear that, in addition to storing calories as triglycerides, adipocytes secrete a large variety of cytokines, chemokines and hormone-like factors, such as leptin, resistin, and acute-phase proteins. In addition, insulin resistance, both in nondiabetic and diabetic subjects, is frequently associated with obesity, particularly with an excess of intraabdominal fat. This production of pro-atherogenic substances is of particular interest since an increase in the plasma levels of these mediators may provide a novel mechanistic link between obesity and its vascular complications.
- Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease?
Internal and Emergency Medicine
Volume 4, Issue 1 , pp 25-34
- Cover Date
- Print ISSN
- Online ISSN
- Springer Milan
- Additional Links
- Adipose tissue
- Cardiovascular risk
- Industry Sectors
- Author Affiliations
- 1. Division of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples, Naples, Italy
- 2. Division of Cardiology, San Sebastiano Hospital, Second University of Naples, Caserta, Italy