IM - Review

Internal and Emergency Medicine

, Volume 4, Issue 1, pp 25-34

Adipose tissue-mediated inflammation: the missing link between obesity and cardiovascular disease?

  • Paolo CalabròAffiliated withDivision of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples Email author 
  • , Enrica GoliaAffiliated withDivision of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples
  • , Valeria MaddaloniAffiliated withDivision of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples
  • , Marco MalvezziAffiliated withDivision of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples
  • , Beniamino CasilloAffiliated withDivision of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples
  • , Carla MarottaAffiliated withDivision of Cardiology, San Sebastiano Hospital, Second University of Naples
  • , Raffaele CalabròAffiliated withDivision of Cardiology, Department of Cardiothoracic Sciences, Second University of Naples
  • , Paolo GolinoAffiliated withDivision of Cardiology, Department of Cardiothoracic Sciences, Second University of NaplesDivision of Cardiology, San Sebastiano Hospital, Second University of Naples

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Abstract

Until relatively recently, the role of adipose tissue in the development of obesity and its consequences was considered to be a passive one. Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. It is now clear that, in addition to storing calories as triglycerides, adipocytes secrete a large variety of cytokines, chemokines and hormone-like factors, such as leptin, resistin, and acute-phase proteins. In addition, insulin resistance, both in nondiabetic and diabetic subjects, is frequently associated with obesity, particularly with an excess of intraabdominal fat. This production of pro-atherogenic substances is of particular interest since an increase in the plasma levels of these mediators may provide a novel mechanistic link between obesity and its vascular complications.

Keywords

Obesity Adipose tissue Inflammation Cardiovascular risk