Do diabetes and obesity promote hepatic fibrosis in familial heterozygous hypobetalipoproteinemia?
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The course of NAFLD secondary to familial heterozygous hypobetalipoproteinemia (FHBL), a definite etiology of secondary nonalcoholic fatty liver disease (NAFLD) [1–3] featuring low density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB) plasma levels less than fifth percentile , is unknown. We report on a case with FHBL due to compound heterozygosity and apoB non-detectable in serum in which a long-term follow-up and paired liver biopsies were available.
A 58 year-old obese woman with FHBL was observed in June 2007 for abdominal pain and poorly controlled type 2 diabetes (T2D). The T2D began at the age of 40. It was complicated by peripheral neuropathy of the legs, and a chronic vascular encephalopathy that was documented by computed tomography. The patient was initially treated with a combination therapy (i.e., metformin plus glibenclamide plus insulin). Additional medications used were gabapentin for the peripheral neuropathy, thiamazole for multinodular hyperthyroidism ...
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- Do diabetes and obesity promote hepatic fibrosis in familial heterozygous hypobetalipoproteinemia?
Internal and Emergency Medicine
Volume 4, Issue 1 , pp 71-73
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- Springer Milan
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- 1. Department of Internal Medicine, Endocrinology, Metabolism and Geriatrics, University of Modena and Reggio Emilia, Nuovo Ospedale Civile Sant’Agostino Estense di Baggiovara, Via Giardini 1355, 41100, Modena, Italy
- 2. Department of Pathology, Azienda Ospedaliero-Universitaria Policlinico di Modena, University of Modena and Reggio Emilia, Via del Pozzo 51, 41100, Modena, Italy