, Volume 3, Issue 3, pp 263-264
Date: 25 Jun 2008

Mankind adaptation and present human health

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The recent review article by Franchini and Mannucci [1] concerning the effects of the evolution of mankind on haemostatic balance through the observed increased prothrombotic risk among Caucasian populations compared to the Afro-Asiatic ones [2, 3] opens another window on the fascinating interaction between the adaptation of mankind and present human health (or modern diseases). It is already well known and quite convincing that some single mutations, such as, for example, the one for lactose tolerance, as well as those prothrombotic related to coagulation factor II and factor V, favouring atherosclerotic and thrombotic events as suggested by Franchini and Mannucci, developed in the millennia between the late Palaeolithic (about 30,000 years ago, the prothrombotic ones) and the early Neolithic (10,000–12,000 years ago, the lactose tolerance) Periods [2, 4].

Palaeoanthropological as well as Archaelogical studies suggest that this was the period of the irreversible, and relatively fast, t ...