, Volume 3, Issue 3, pp 201-203
Date: 01 Jul 2008

Aspirin in asymptomatic patients with confirmed positivity of antiphospholipid antibodies? Yes (in some cases)

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Although treatment for some individual clinical conditions are still a matter of debate, there is a general agreement on the therapy for preventing recurrences of thrombosis or pregnancy loss in patients suffering from antiphospholipid syndrome (APS) [rev. in 1]. However, there are no clear statements as how to deal with subjects persistently positive for anti-phospholipid antibodies (aPL) but asymptomatic for vascular/obstetric manifestations associated to APS or lacking the formal classification criteria for APS [25].

The detection of aPL is a formal diagnostic step for the APS diagnosis [6]. In addition, aPL have been reported as prognostic risk factors for recurrent arterial/venous thrombotic events as well as for pregnancy loss [6]. Nevertheless, their predictive value for the vascular manifestations of the syndrome in particular is still a matter of debate. In fact, not only the autoantibody titers, but also the isotype and the type of the assay used for aPL detection are apparen ...